Western Blot (WB)
(Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain using GSK3beta Monoclonal Antibody at dilution of 1:1000.)
Mouse GSK3beta Monoclonal Antibody | anti-GSK3beta antibody
GSK3beta Monoclonal Antibody
IHC: 1:100-200
Western Blot (WB)
(Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain using GSK3beta Monoclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain using GSK3beta Monoclonal Antibody at dilution of 1:1000.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using GSK3beta Monoclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using GSK3beta Monoclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human stomach carcinoma tissue using GSK3beta Monoclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human stomach carcinoma tissue using GSK3beta Monoclonal Antibody at dilution of 1:200.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Uniprot Description
GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation
Protein type: CMGC group; EC 2.7.11.1; EC 2.7.11.26; GSK family; GSK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: beta-catenin destruction complex; centrosome; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; Wnt signalosome
Molecular Function: ATP binding; beta-catenin binding; kinase activity; NF-kappaB binding; p53 binding; protease binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau-protein kinase activity; ubiquitin protein ligase binding
Biological Process: beta-catenin destruction complex assembly; beta-catenin destruction complex disassembly; cellular response to amyloid-beta; circadian rhythm; dopamine receptor signaling pathway; epithelial to mesenchymal transition; ER overload response; glycogen metabolic process; hippocampus development; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of dopaminergic neuron differentiation; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of neuron death; negative regulation of NFAT protein import into nucleus; negative regulation of protein binding; negative regulation of protein complex assembly; negative regulation of protein localization to nucleus; negative regulation of type B pancreatic cell development; neuron projection development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; protein autophosphorylation; regulation of apoptosis; regulation of cellular response to heat; regulation of microtubule-based process; superior temporal gyrus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Research Articles on GSK3beta
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Product Notes
The GSK3beta gsk3b (Catalog #AAA2548907) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GSK3beta Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GSK3beta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. WB: 1:1000-2000 IHC: 1:100-200. Researchers should empirically determine the suitability of the GSK3beta gsk3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSK3beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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