Immunohistochemistry (IHC)
(Glypican-3 [IHC405] on Liver)
Mouse anti-Human Glypican-3 Monoclonal Antibody | anti-GPC3 antibody
Glypican-3
Reactivity
Human
Synonyms
Glypican-3; Monoclonal Antibody; anti-GPC3 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Sequence Length
355
Application Notes
The recommended working dilution range is 1:100-1:200
Positive Control
Hepatocellular Carcinoma
Immunohistochemistry (IHC)
(Glypican-3 [IHC405] on Liver)
Immunohistochemistry (IHC)
(Glypican-3 [IHC405] on Liver)
Related Product Information for anti-GPC3 antibody
Glypican-3 (GPC3) is a GPI-archored proteoglycan involved in cell division and growth regulation. Glypican-3 is a useful tumor marker, and its expression has been shown to be upregulated in hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms' tumor. Patients with HCC have presented elevated levels of GPC3 in the neoplastic liver tissues and serum, which is higher than cirrhotic liver or liver with focal lesions including those with hepatic adenoma and dysplastic nodules. Glypican-3 is also overexpressed in testicular germ cell tumors of certain subtypes, such as yolk sac tumors and choriocarcinoma, and in embryonal tumors.
References
1. Capurro M, et al. Gastroenterology. 2003; 125:89-97.
2. Coston WMP, et al. Am J Surg Pathol. 2008; 32:433-44.
3. Kandil D, et al. Cancer. 2007; 111:316-22.
4. Zynger DL, et al. Hum Pathol. 2008; 39:224-30.
5. Kandil DH, et al. Adv Anat Pathol. 2009; 16:125-9.
6. Zynger DL, et al. Am J Surg Pathol. 2006; 30:1570-5.
2. Coston WMP, et al. Am J Surg Pathol. 2008; 32:433-44.
3. Kandil D, et al. Cancer. 2007; 111:316-22.
4. Zynger DL, et al. Hum Pathol. 2008; 39:224-30.
5. Kandil DH, et al. Adv Anat Pathol. 2009; 16:125-9.
6. Zynger DL, et al. Am J Surg Pathol. 2006; 30:1570-5.
NCBI and Uniprot Product Information
Uniprot Description
Cell surface proteoglycan that bears heparan sulfate.
Similar Products
Product Notes
The Glypican-3 gpc3 (Catalog #AAA344030) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Glypican-3 reacts with Human and may cross-react with other species as described in the data sheet. The recommended working dilution range is 1:100-1:200. Researchers should empirically determine the suitability of the Glypican-3 gpc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glypican-3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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