Glypican-3/GPC3/OCI5 Recombinant Protein | GPC3/OCI5 recombinant protein

Recombinant Mouse Glypican-3/GPC3/OCI5 (C-6His)

Cat. Num. AAA2569331

• Gene Names: Gpc3; OCI-5
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Glypican-3/GPC3/OCI5; Recombinant Mouse Glypican-3/GPC3/OCI5 (C-6His); Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5; GPC3/OCI5 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, 5% Trehalose, pH7.4.
• Sequence: Gln25-Met557

• Species: Mouse
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-Met557 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

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Related Product Information for GPC3/OCI5 recombinant protein

Glypican-3/GPC3 is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

NCBI and Uniprot Product Information

• NCBI GI #: 31980680
• NCBI GeneID: 14734
• NCBI Accession #: NP_057906.2
• NCBI GenBank Nucleotide #: NM_016697.3
• UniProt Accession #: Q8CFZ4
• Molecular Weight: 65,332 Da
• NCBI Official Full Name: glypican-3
• NCBI Official Synonym Full Names: glypican 3
• NCBI Official Symbol: Gpc3
• NCBI Official Synonym Symbols: OCI-5
• NCBI Protein Information: glypican-3
• UniProt Protein Name: Glypican-3
• UniProt Gene Name: Gpc3

Uniprot Description

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition ().