Mouse anti-Human, Mouse Furin Convertase, Region 2 Monoclonal Antibody | anti-FURIN antibody
Furin Convertase, Region 2
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Dilution: Immunocytochemistry: 1:200-1:400
Immunoprecipitation: 1:200 (50mM Tris/HCl, pH 7.4, 150mM sodium chloride, 1% Triton X-100; 1% sodium deoxycholate, 0.1% SDS)
Western Blot: 1:1000
Optimal dilution to be determined by the researcher.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
FURIN: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: EC 3.4.21.75; Membrane protein, integral; Cell surface; Vesicle; Protease
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: Golgi membrane; extracellular space; trans-Golgi network transport vesicle; cell surface; membrane; Golgi lumen; integral to membrane; plasma membrane; trans-Golgi network; lipid raft
Molecular Function: serine-type endopeptidase inhibitor activity; peptidase activity; protease binding; serine-type endopeptidase activity; metal ion binding; endopeptidase activity; nerve growth factor binding; peptide binding
Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; viral reproduction; peptide hormone processing; regulation of signal transduction; pathogenesis; viral infectious cycle; proteolysis; positive regulation of membrane protein ectodomain proteolysis; peptide biosynthetic process; extracellular matrix disassembly; nerve growth factor processing; transforming growth factor beta receptor signaling pathway; regulation of endopeptidase activity; negative regulation of nerve growth factor production; secretion by cell; Notch signaling pathway; signal peptide processing; virus assembly; post-translational protein modification; peptidyl-glutamic acid carboxylation; nerve growth factor production; negative regulation of transforming growth factor-beta1 production; collagen catabolic process; cell proliferation; cellular protein metabolic process; viral protein processing; regulation of protein catabolic process; protein processing; negative regulation of low-density lipoprotein receptor catabolic process
Research Articles on FURIN
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Product Notes
The FURIN furin (Catalog #AAA600783) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Furin Convertase, Region 2 reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Furin Convertase, Region 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC). Suitable for use in Immunocytochemistry, Immunoprecipitation, and Western Blot. Dilution: Immunocytochemistry: 1:200-1:400 Immunoprecipitation: 1:200 (50mM Tris/HCl, pH 7.4, 150mM sodium chloride, 1% Triton X-100; 1% sodium deoxycholate, 0.1% SDS) Western Blot: 1:1000 Optimal dilution to be determined by the researcher. Researchers should empirically determine the suitability of the FURIN furin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Furin Convertase, Region 2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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