Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant FOXA2 protein (Right) or empty vector (Left) detected with FOXA2 antibody)
Mouse FOXA2 Monoclonal Antibody | anti-FOXA2 antibody
FOXA2 antibody
IF: 1:100
IHC: 1:50
WB: 1:1000
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant FOXA2 protein (Right) or empty vector (Left) detected with FOXA2 antibody)
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant FOXA2 protein (Right) or empty vector (Left) detected with FOXA2 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of FOXA2 protein in paraffin embedded Human lung tissue using FOXA2 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of FOXA2 protein in paraffin embedded Human lung tissue using FOXA2 antibody)
Immunofluorescence (IF)
(Immunofluorescent staining of Hela cells transiently transfected with recombinant FOXA2 protein using FOXA2 antibody)
Immunofluorescence (IF)
(Immunofluorescent staining of Hela cells transiently transfected with recombinant FOXA2 protein using FOXA2 antibody)
NCBI and Uniprot Product Information
Uniprot Description
FOXA2: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 20p11
Cellular Component: cytoplasm; nucleus
Molecular Function: protein domain specific binding; DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; adult locomotory behavior; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter by glucose; cell fate specification; negative regulation of glucokinase activity; cell differentiation in hindbrain; ectoderm formation; regulation of steroid metabolic process; positive regulation of smoothened signaling pathway; neuron fate specification; positive regulation of transcription from RNA polymerase II promoter by glucose; dorsoventral neural tube patterning; in utero embryonic development; negative regulation of transcription factor activity; chromatin modification; somite rostral/caudal axis specification; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; positive regulation of embryonic development; regulation of blood coagulation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell development
Similar Products
Product Notes
The FOXA2 foxa2 (Catalog #AAA830368) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's FOXA2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). FC: 1:1000 IF: 1:100 IHC: 1:50 WB: 1:1000. Researchers should empirically determine the suitability of the FOXA2 foxa2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOXA2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
