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Western Blot (WB) (The cell lysates of MCF7 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FKBP6 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.)

Mouse anti-Human FKBP6 Monoclonal Antibody | anti-FKBP6 antibody

FKBP6 antibody

Gene Names
FKBP6; FKBP36
Reactivity
Human
Applications
ELISA, Western Blot
Purity
By protein-A affinity chromatography
Synonyms
FKBP6; Monoclonal Antibody; FKBP6 antibody; FK506 binding protein 6 36kDa; FKBP36; PPIase FKBP6; FK506 binding protein 6; 36kDa 36 kDa FK506 binding protein; EC 5.2.1.8; FKBP 36; Immunophilin FKBP36; Peptidyl prolyl cis trans isomerase; PPIase; Rotamase.; anti-FKBP6 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
AT9B7
Purity/Purification
By protein-A affinity chromatography
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
327
Applicable Applications for anti-FKBP6 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Recommended starting dilution is 1:1000.
Antigen Species
Human
Immunogen
Recombinant human FKBP6 (1-327aa) purified from E. coli
Clone Note
Anti-human FKBP6 mAb, clone AT9B7, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FKBP6 protein.
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.

Western Blot (WB)

(The cell lysates of MCF7 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FKBP6 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.)

Western Blot (WB) (The cell lysates of MCF7 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FKBP6 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.)
Related Product Information for anti-FKBP6 antibody
FKBP6 (FK506 binding protein 6) is a 327 amino acid protein. FKBP6 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. FKBP6 is ubiquitously expressed in all tissues, with higher expressed in testis, heart, skeletal muscle, liver, and kidney. Deletion of FKBP6 may contribute to hypercalcemia and growth delay in Williams-Beuren syndrome.
Product Categories/Family for anti-FKBP6 antibody
References
Meng. X., et al. (1998) Genomics 52: 130-137; Crackower. M.A., et al. (2003) Science 300: 1291-1295; Metcalfe. K., et al. (2005) Clin Dysmorphol 14: 61-65;

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33,553 Da
NCBI Official Full Name
inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform a
NCBI Official Synonym Full Names
FK506 binding protein 6
NCBI Official Symbol
FKBP6
NCBI Official Synonym Symbols
FKBP36
NCBI Protein Information
inactive peptidyl-prolyl cis-trans isomerase FKBP6
UniProt Protein Name
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Protein Family
UniProt Gene Name
FKBP6
UniProt Synonym Gene Names
FKBP36; Inactive PPIase FKBP6; 36 kDa FKBP; FKBP-36; FKBP-6

NCBI Description

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes ().

Research Articles on FKBP6

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Product Notes

The FKBP6 fkbp6 (Catalog #AAA200259) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FKBP6 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FKBP6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Recommended starting dilution is 1:1000. Researchers should empirically determine the suitability of the FKBP6 fkbp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FKBP6, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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