Western Blot (WB)
(FKBP6 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FKBP6 antibody detected the FKBP6 protein (arrow).)
Rabbit anti-Human FKBP6 Polyclonal Antibody | anti-FKBP6 antibody
FKBP6 Antibody (C-term)
Western Blot (WB)
(FKBP6 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FKBP6 antibody detected the FKBP6 protein (arrow).)
Western Blot (WB)
(FKBP6 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FKBP6 antibody detected the FKBP6 protein (arrow).)
immunophilin protein family, which play a role in immunoregulation
and basic cellular processes involving protein folding and
trafficking. The protein may have cis-trans prolyl isomerase
activity, and binds to clathrin heavy chain and heat shock protein
72. This gene is found to be deleted in Williams syndrome, and the
orthologous gene in mouse is essential for fertility and homologous
pairing in male meiosis.
Jarczowski, F., et al. J. Biol. Chem. 284(2):766-773(2009)
Jarczowski, F., et al. Biochemistry 47(26):6946-6952(2008)
Zhang, W., et al. Reproduction 133(2):511-516(2007)
Miyamato, T., et al. Cell. Mol. Biol. Lett. 11(4):557-569(2006)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: endoplasmic reticulum membrane; cytoplasm; synaptonemal complex; cytosol
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; Hsp90 protein binding
Biological Process: meiosis; protein peptidyl-prolyl isomerization; protein folding; DNA methylation during gametogenesis; spermatogenesis; RNA-mediated gene silencing; cell differentiation
Research Articles on FKBP6
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Product Notes
The FKBP6 fkbp6 (Catalog #AAA9214134) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 256-284. The FKBP6 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FKBP6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the FKBP6 fkbp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FKBP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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