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Testing Data
Testing Data (Detection of human FGL2 with MBS605615. Lysates were prepared from human peripheral blood mononuclear cells in reducing sample buffer, resolved by SDS-PAGE (30ug total protein/lane), and transferred to an Immobilon-P membrane. The blot was developed with 2ug/ml MBS605615 and chemiluminescent detection substrate.)

Mouse anti-Human Fibrinogen-like Protein 2 Monoclonal Antibody | anti-FGL2 antibody

Fibrinogen-like Protein 2 (FGL2, Fibrinogen-like 2, Fibroleukin, pT49, T49)

Gene Names
FGL2; T49; pT49
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified by Protein A affinity chromatography.
Synonyms
Fibrinogen-like Protein 2; Monoclonal Antibody; Fibrinogen-like Protein 2 (FGL2; Fibrinogen-like 2; Fibroleukin; pT49; T49); Anti -Fibrinogen-like Protein 2 (FGL2; anti-FGL2 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9L828
Specificity
Recognizes human Fibrinogen-like Protein 2. Does not cross react with recombinant human Angiopoietin-1, recombinant human Angiopoitein-2, recombinant human Angiopoitin-like 2 or recombinant Mouse Angiopoietin-3
Purity/Purification
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
Applicable Applications for anti-FGL2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Western Blot: 2ug/ml using human peripheral lood mononuclear cells
Optimal working dilutions to be determined by the researcher
Immunogen
Recombinant protein corresponding to Asn24-Pro439 of human Fibrinogen-like Protein 2, expressed in CHO.
Grade
Affinity Purified
Hybridoma
Mouse myeloma cells with B cells obtained from a mouse immunized with purified, CHO-derived, recombinant human FGL2 (aa24-439).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

(Detection of human FGL2 with MBS605615. Lysates were prepared from human peripheral blood mononuclear cells in reducing sample buffer, resolved by SDS-PAGE (30ug total protein/lane), and transferred to an Immobilon-P membrane. The blot was developed with 2ug/ml MBS605615 and chemiluminescent detection substrate.)

Testing Data (Detection of human FGL2 with MBS605615. Lysates were prepared from human peripheral blood mononuclear cells in reducing sample buffer, resolved by SDS-PAGE (30ug total protein/lane), and transferred to an Immobilon-P membrane. The blot was developed with 2ug/ml MBS605615 and chemiluminescent detection substrate.)
Related Product Information for anti-FGL2 antibody
Fibrinogen-like Protein 2 (FGL2, Fibroleukin) is a 64-70kD secreted glycoprotein of the fibrinogen-like superfamily. It is produced by macrophages and endothelial cells in response to inflammatory mediators, T cells and fetal trophoblast cells. FGL2 has prothrombinase activity, promotes immune-mediated thrombosis and functions in transplant rejection and infection-related abortion. Mature human FGL2 gene is a 416aa protein with a coiled-coil region and a fibronectin C-terminal homology domain or FRED. Coiled-coil dimers are covalently linked to form a tetrameric 260-280aa FGL2 complex. Mature human FGL2 shares 79% aa identity with mouse FGL2.
Product Categories/Family for anti-FGL2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
50,229 Da
NCBI Official Full Name
fibroleukin
NCBI Official Synonym Full Names
fibrinogen-like 2
NCBI Official Symbol
FGL2
NCBI Official Synonym Symbols
T49; pT49
NCBI Protein Information
fibroleukin; fibrinogen-like protein 2
UniProt Protein Name
Fibroleukin
Protein Family
UniProt Gene Name
FGL2
UniProt Entry Name
FGL2_HUMAN

NCBI Description

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

Uniprot Description

FGL2: May play a role in physiologic lymphocyte functions at mucosal sites.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: fibrinogen complex

Research Articles on FGL2

1. Circulating fibrinogen-like protein 2 is increased in patients with systemic sclerosis.

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Product Notes

The FGL2 fgl2 (Catalog #AAA605615) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Fibrinogen-like Protein 2 (FGL2, Fibrinogen-like 2, Fibroleukin, pT49, T49) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fibrinogen-like Protein 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB)Precautions All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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