Rabbit anti-Human, Mouse LONP2 Polyclonal Antibody | anti-LONP2 antibody

LONP2, NT (LONP2, LONP, Lon protease homolog 2, peroxisomal, Lon protease-like protein 2, Peroxisomal Lon protease) (AP)

Cat. Num. AAA6316713

• Gene Names: LONP2; LONP; LONPL
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LONP2; Polyclonal Antibody; NT (LONP2; LONP; Lon protease homolog 2; peroxisomal; Lon protease-like protein 2; Peroxisomal Lon protease) (AP); Peroxisomal Lon protease; anti-LONP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-LONP2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LONP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111~140 amino acids from the N-terminal region of human LONP2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of LONP2 Antibody (N-term) in mouse brain tissue lysates (35ug/lane). LONP2 (arrow) was detected using the purified Pab.)

Related Product Information for anti-LONP2 antibody

LONP2 is probable serine protease which may be involved in peroxisome biogenesis (By similarity).

Product Categories/Family for anti-LONP2 antibody

Antibodies; Enzymes; Protease (Proteinase; Peptidase)

References

Omi, S., et al. J. Biochem. 143(5):649-660(2008). Kikuchi, M., et al. J. Biol. Chem. 279(1):421-428(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 31377667
• NCBI GeneID: 83752
• NCBI Accession #: NP_113678.2
• NCBI GenBank Nucleotide #: NM_031490.2
• UniProt Accession #: Q86WA8; Q0D2H6; Q8N3B9; Q8NCE9; Q96K43
• Molecular Weight: 94,617 Da
• NCBI Official Full Name: lon protease homolog 2, peroxisomal
• NCBI Official Synonym Full Names: lon peptidase 2, peroxisomal
• NCBI Official Symbol: LONP2
• NCBI Official Synonym Symbols: LONP; LONPL
• NCBI Protein Information: lon protease homolog 2, peroxisomal; lon protease 2; lon protease-like protein 2; peroxisomal LON protease like; peroxisomal Lon protease homolog 2
• UniProt Protein Name: Lon protease homolog 2, peroxisomal
• UniProt Gene Name: LONP2
• UniProt Synonym Gene Names: LONP; Lon protease 2
• UniProt Entry Name: LONP2_HUMAN

Uniprot Description

LONP2: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family.

Protein type: Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: peroxisomal matrix; membrane; peroxisome; nucleus

Molecular Function: peptidase activity; protein binding; enzyme binding; protease binding; ATP-dependent peptidase activity; serine-type endopeptidase activity; ATP binding; receptor binding

Biological Process: protein targeting to peroxisome; peroxisome organization and biogenesis; misfolded or incompletely synthesized protein catabolic process; protein import into peroxisome matrix; regulation of fatty acid beta-oxidation; protein processing; response to organic cyclic substance