Mouse anti-Human FABP1 / L-FABP Monoclonal Antibody | anti-FABP1 antibody

Mouse Monoclonal [clone 2G4] (IgG1,k) to Human FABP1 / L-FABP

Cat. Num. AAA245369

• Gene Names: FABP1; FABPL; L-FABP
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Protein G Purified
• Synonyms: FABP1 / L-FABP; Monoclonal Antibody; Mouse Monoclonal [clone 2G4] (IgG1; k) to Human FABP1 / L-FABP; Anti-FABP1 / L-FABP Antibody (aa1-127; clone 2G4) IHC-plus; FABP1; FABPL; L-FABP; Fatty acid-binding protein 1; Human FABP1; anti-FABP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 2G4
• Purity/Purification: Protein G Purified
• Form/Format: PBS, pH 7.4, 0.1% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 127

• Applicable Applications for anti-FABP1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1:1000 - 1:2000); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Recombinant human FABP1 (1-127aa) purified from E Coli. NCBI Accession No.: NP_001434.
• Immunogen Type: Recombinant protein
• Immunogen: FABP1 / L-FABP antibody was raised against recombinant human FABP1 (1-127aa) purified from E Coli. NCBI Accession No.: NP_001434.
• Antigen Modification: aa1-127
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-FABP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-FABP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Cell lysates of HepG2 (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human FABP1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.)

Related Product Information for anti-FABP1 antibody

FABP1 encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

NCBI and Uniprot Product Information

• NCBI GI #: 4557577
• NCBI GeneID: 2168
• NCBI Accession #: NP_001434.1
• NCBI GenBank Nucleotide #: NM_001443.2
• UniProt Accession #: P07148
• Molecular Weight: 14,208 Da
• NCBI Official Full Name: fatty acid-binding protein, liver
• NCBI Official Synonym Full Names: fatty acid binding protein 1, liver
• NCBI Official Symbol: FABP1
• NCBI Official Synonym Symbols: FABPL; L-FABP
• NCBI Protein Information: fatty acid-binding protein, liver; fatty acid-binding protein 1; liver-type fatty acid-binding protein
• UniProt Protein Name: Fatty acid-binding protein, liver
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP1
• UniProt Synonym Gene Names: FABPL; L-FABP
• UniProt Entry Name: FABPL_HUMAN

NCBI Description

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

Uniprot Description

FABP1: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 2p11

Cellular Component: nucleoplasm; peroxisomal matrix; apical cortex; cytosol

Molecular Function: antioxidant activity; bile acid binding; phospholipid binding; chromatin binding; long-chain fatty acid transporter activity; drug binding; fatty acid binding

Biological Process: long-chain fatty acid transport; positive regulation of cell proliferation; positive regulation of hydrolase activity; cellular lipid metabolic process; negative regulation of caspase activity; positive regulation of fatty acid beta-oxidation; negative regulation of apoptosis; intestinal absorption