Mouse Estrogen Receptor beta Monoclonal Antibody | anti-Esr2 antibody
Estrogen Receptor- beta Monoclonal Antibody
This antibody recognizes human ER- beta , a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER- beta are very similar to ER- alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER- alpha , ER- beta binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements
Positive controls: Native receptor from human thymus, spleen, ovary, and testisor recombinant protein.
NCBI and Uniprot Product Information
NCBI Description
binds estrogen and mediates transcriptional activation [RGD]
Uniprot Description
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Protein type: Nuclear receptor; DNA-binding
Cellular Component: neuron projection; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium
Molecular Function: ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; estrogen receptor activity; hormone binding; zinc ion binding; estrogen response element binding; drug binding; steroid binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity
Biological Process: prostate gland development; hypothalamus development; behavioral fear response; estrogen receptor signaling pathway; induction of apoptosis by hormones; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; amygdala development; negative regulation of transcription from RNA polymerase II promoter; response to insecticide; uterus development; response to organic cyclic substance; response to estradiol stimulus; negative regulation of cell proliferation; learning and/or memory; ovarian follicle development; regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; cerebellum development; female gonad development; negative regulation of epithelial cell proliferation; response to nutrient levels; steroid hormone receptor signaling pathway; response to drug; transcription, DNA-dependent; male gonad development; vagina development; Sertoli cell proliferation; response to testosterone stimulus; Sertoli cell development; regulation of cell proliferation; response to genistein; response to ethanol; response to estrogen stimulus; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of transcription factor activity; brain development; response to activity; negative regulation of behavior; response to water deprivation
Research Articles on Esr2
Similar Products
Product Notes
The Esr2 esr2 (Catalog #AAA190148) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Estrogen Receptor beta can be used in a range of immunoassay formats including, but not limited to, Immunoblot. Immunoblotting: use at 1-5 ug/ml. Positive controls: Native receptor from human thymus, spleen, ovary, and testisor recombinant protein. Researchers should empirically determine the suitability of the Esr2 esr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Estrogen Receptor beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
