Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Mouse anti-Human Episialin, EMA Monoclonal Antibody | anti-MUC1 antibody
Anti-Episialin, EMA antibody (monoclonal)
Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Episialin, EMA antibody, MBS175095, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Background: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1(EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type I transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
NCBI and Uniprot Product Information
Uniprot Description
MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Tumor suppressor; Membrane protein, integral; Nuclear receptor co-regulator; Actin-binding
Cellular Component: cell surface; membrane; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; nucleus
Research Articles on MUC1
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Product Notes
The MUC1 muc1 (Catalog #AAA175095) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Episialin, EMA antibody (monoclonal) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Episialin, EMA can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin. Researchers should empirically determine the suitability of the MUC1 muc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Episialin, EMA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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