Mouse Elongation Factor RNA Polymerase II Monoclonal Antibody | anti-ELL antibody

Elongation Factor RNA Polymerase II (C19orf17, DKFZp434I1916, ELL, ELL1, Men)

Cat. Num. AAA608813

• Gene Names: ELL; MEN; ELL1; C19orf17; DKFZp434I1916
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Elongation Factor RNA Polymerase II; Monoclonal Antibody; Elongation Factor RNA Polymerase II (C19orf17; DKFZp434I1916; ELL; ELL1; Men); Anti -Elongation Factor RNA Polymerase II (C19orf17; anti-ELL antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8C128
• Specificity: Recognizes human Elongation Factor RNA Polymerase II.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-ELL antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human Elongation Factor RNA Polymerase II
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-ELL antibody

Antibodies; Abs to Enzymes; Polymerase

NCBI and Uniprot Product Information

• NCBI GI #: 29165820
• NCBI GeneID: 8178
• UniProt Accession #: P55199; Q59HG4; Q75MS0
• Molecular Weight: 68,265 Da
• NCBI Official Full Name: Elongation factor RNA polymerase II
• NCBI Official Synonym Full Names: elongation factor RNA polymerase II
• NCBI Official Symbol: ELL
• NCBI Official Synonym Symbols: MEN; ELL1; C19orf17; DKFZp434I1916
• NCBI Protein Information: RNA polymerase II elongation factor ELL; ELL gene (11-19 lysine-rich leukemia gene); eleven-nineteen lysine-rich leukemia protein
• UniProt Protein Name: RNA polymerase II elongation factor ELL
• Protein Family: RNA polymerase II elongation factor
• UniProt Gene Name: ELL
• UniProt Synonym Gene Names: C19orf17
• UniProt Entry Name: ELL_HUMAN

Uniprot Description

ELL: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. Belongs to the ELL/occludin family.

Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; Cajal body; transcription elongation factor complex; nuclear speck

Molecular Function: protein binding; phosphatase binding

Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; in utero embryonic development; positive regulation of RNA elongation; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; gene expression; snRNA transcription from RNA polymerase III promoter