Western Blot (WB)
(Western Blotting Analysis: Representative lot data. HeLa S3 cell lysate was probed with Anti-PRUNE (0.05ug/ml). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates PRUNE (~57kD))
Rabbit anti-Human PRUNE Polyclonal Antibody | anti-PRUNE antibody
PRUNE (Protein Prune Homolog, hPrune, Drosophila-related Expressed Sequence 17, DRES17, DRES-17, HTcD37) (MaxLight 550)
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. HeLa S3 cell lysate was probed with Anti-PRUNE (0.05ug/ml). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates PRUNE (~57kD))
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. HeLa S3 cell lysate was probed with Anti-PRUNE (0.05ug/ml). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates PRUNE (~57kD))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Description
PRUNE: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. Belongs to the PPase class C family. Prune subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Nucleotide Metabolism - purine; EC 3.6.1.1
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: focal adhesion; cytoplasm; nucleus
Molecular Function: protein binding; inorganic diphosphatase activity; metal ion binding
Biological Process: metabolic process
Research Articles on PRUNE
Similar Products
Product Notes
The PRUNE prune (Catalog #AAA6444794) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PRUNE (Protein Prune Homolog, hPrune, Drosophila-related Expressed Sequence 17, DRES17, DRES-17, HTcD37) (MaxLight 550) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PRUNE can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:5000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PRUNE prune for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRUNE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
