Testing Data
(Immunolocalization of BMP4 (red) in the lateral ventricle area of P7 mouse CNS. The blue stain is Hoechst nuclear counter stain. Photo courtesy of Dr. Jason Emsley, Harvard Medical School, Boston, MA.)
Mouse Bone Morphogenetic Protein 4 Monoclonal Antibody | anti-BMP4 antibody
Bone Morphogenetic Protein 4 (BMP4, DVR4) (AP)
Testing Data
(Immunolocalization of BMP4 (red) in the lateral ventricle area of P7 mouse CNS. The blue stain is Hoechst nuclear counter stain. Photo courtesy of Dr. Jason Emsley, Harvard Medical School, Boston, MA.)
Testing Data
(Immunolocalization of BMP4 (red) in the lateral ventricle area of P7 mouse CNS. The blue stain is Hoechst nuclear counter stain. Photo courtesy of Dr. Jason Emsley, Harvard Medical School, Boston, MA.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transforming growth factor beta superfamily of regulatory proteins that plays an important role in the process of bone and cartilage development. The encoded preproprotein undergoes proteolytic processing to generate a disulfide linked homodimeric glycoprotein. Mice lacking the encoded protein die in utero. Transgenic mice overexpressing the encoded protein in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Oct 2015]
Uniprot Description
BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: cytoplasm; extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: chemoattractant activity; cytokine activity; growth factor activity; heparin binding; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding
Biological Process: activation of MAPKK activity; alveolus development; anatomical structure formation; angiogenesis; anterior/posterior axis specification; blood vessel development; blood vessel endothelial cell proliferation during sprouting angiogenesis; BMP signaling pathway; branching morphogenesis of a tube; camera-type eye development; camera-type eye morphogenesis; cardiac muscle cell differentiation; cartilage development; cell differentiation; cell fate commitment; chondrocyte differentiation; common-partner SMAD protein phosphorylation; dorsoventral neural tube patterning; embryonic cranial skeleton morphogenesis; embryonic digit morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic morphogenesis; embryonic skeletal development; embryonic skeletal morphogenesis; endochondral ossification; erythrocyte differentiation; eye development; forebrain development; germ cell development; growth; heart development; hemopoietic progenitor cell differentiation; induction of an organ; inner ear receptor cell differentiation; intermediate mesodermal cell differentiation; kidney development; lung development; lymphoid progenitor cell differentiation; macrophage differentiation; mesoderm formation; mesodermal cell differentiation; mesodermal cell fate determination; metanephros development; monocyte differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of epithelial cell proliferation; negative regulation of immature T cell proliferation in the thymus; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of myoblast differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of phosphorylation; negative regulation of striated muscle development; negative regulation of T cell differentiation in the thymus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural tube closure; neuron fate commitment; odontogenesis; odontogenesis of dentine-containing teeth; ossification; osteoblast differentiation; ovarian follicle development; pituitary gland development; positive chemotaxis; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of cardiac muscle fiber development; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of epidermal cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of neuron differentiation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vascular endothelial growth factor receptor signaling pathway; post-embryonic development; regulation of cell differentiation; regulation of cell fate commitment; regulation of endothelial cell proliferation; regulation of gene expression; regulation of odontogenesis of dentine-containing teeth; regulation of protein import into nucleus; regulation of smooth muscle cell differentiation; regulation of smooth muscle cell proliferation; renal system process; skeletal development; smooth muscle cell differentiation; smooth muscle development; specification of organ position; steroid hormone mediated signaling; telencephalon development; telencephalon regionalization; tissue development; ureteric bud branching; ureteric bud development; vasculature development
Research Articles on BMP4
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Product Notes
The BMP4 bmp4 (Catalog #AAA6241839) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Bone Morphogenetic Protein 4 (BMP4, DVR4) (AP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Bone Morphogenetic Protein 4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunocytochemistry (ICC), Western Blot (WB). Researchers should empirically determine the suitability of the BMP4 bmp4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bone Morphogenetic Protein 4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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