Rabbit anti-Human DSC2  Monoclonal Antibody | anti-DSC2  antibody

Rabbit anti Human DSC2  Monoclonal Antibody

Cat. Num. AAA2544082

• Gene Names: DSC2; DG2; DSC3; CDHF2; ARVD11; DGII/III
• Reactivity: Human
• Applications: ELISA
• Synonyms: DSC2 ; Monoclonal Antibody; Rabbit anti Human DSC2 Monoclonal Antibody; anti-DSC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 847

• Applicable Applications for anti-DSC2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human DSC2. The detection limit for Human DSC2 is approximately 0.00975 ng/well.
• Immunogen: Recombinant Human DSC2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-DSC2  antibody

DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 13435366
• NCBI GeneID: 1824
• NCBI GenBank Nucleotide #: NM_004949.4
• Molecular Weight: 93,769 Da
• NCBI Official Full Name: desmocollin-2 isoform Dsc2b preproprotein
• NCBI Official Synonym Full Names: desmocollin 2
• NCBI Official Symbol: DSC2
• NCBI Official Synonym Symbols: DG2; DSC3; CDHF2; ARVD11; DGII/III
• NCBI Protein Information: desmocollin-2
• UniProt Protein Name: Desmocollin-2
• UniProt Gene Name: DSC2
• UniProt Synonym Gene Names: CDHF2; DSC3
• UniProt Entry Name: DSC2_HUMAN

NCBI Description

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.