Immunohistochemistry - Paraffin (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Mouse anti-Human DMN / Desmuslin / Synemin Monoclonal Antibody | anti-DMN antibody
Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) IHC-plus
Immunohistochemistry - Paraffin (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Colon, Submucosa: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Colon, Submucosa: Formalin-Fixed, Paraffin-Embedded (FFPE))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DMN: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Belongs to the intermediate filament family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: adherens junction; costamere; intermediate filament; membrane; neurofilament cytoskeleton
Molecular Function: intermediate filament binding; protein binding; structural constituent of cytoskeleton; structural constituent of muscle; vinculin binding
Biological Process: intermediate filament cytoskeleton organization and biogenesis
Research Articles on DMN
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Product Notes
The DMN synm (Catalog #AAA249433) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DMN / Desmuslin / Synemin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin. IHC-P (10 ug/ml). Researchers should empirically determine the suitability of the DMN synm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DMN / Desmuslin / Synemin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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