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Mouse anti-Human DLL3 Monoclonal Antibody | anti-DLL3 antibody

DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3)

Gene Names
DLL3; SCDO1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified by Protein A chromatography from hybridoma culture supernatant.
Synonyms
DLL3; Monoclonal Antibody; DLL3 (Delta-like Protein 3; Drosophila Delta Homolog 3; Delta3); Anti -DLL3 (Delta-like Protein 3; anti-DLL3 antibody
Ordering
 
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For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
7H171
Specificity
Recognizes human DLL3. Does not crossreact with recombinant human DLL1 or recombinant human DLL4.
Purity/Purification
Purified by Protein A chromatography from hybridoma culture supernatant.
Form/Format
Supplied as a lyophilized powder from PBS, pH7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
Concentration
~0.5mg/ml(after reconstitution) (varies by lot)
Applicable Applications for anti-DLL3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Western Blot: 1ug/ml using recombinant human DLL3
Optimal dilutions to be determined by the researcher.
Other applications not tested.
Immunogen
Recombinant protein corresponding to Ala27-Pro488 from human DLL3 expressed in CHO cells.
Grade
Affinity Purified
Preparation and Storage
Lyophilized and reconstituted products are stable for 12 months after receipt at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-DLL3 antibody
Delta-like 3 (DLL3) is a transmembrane Delta-like protein that contains one DSL domain and six EGF-like repeats. DLL3 is critical for somite segmentation and neurogenesis during early embryonic development. It does not bind Notch receptors but functions as an antagonist of Notch signaling. Defects in DLL3 cause axial skeletal abnormalities in spondylocostal dysostosis. Within the extracellular domain, human DLL3 shares 84% amino acid sequence identity with mouse and rat DLL3.
Product Categories/Family for anti-DLL3 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
delta-like protein 3 isoform 2
NCBI Official Synonym Full Names
delta-like 3 (Drosophila)
NCBI Official Symbol
DLL3
NCBI Official Synonym Symbols
SCDO1
NCBI Protein Information
delta-like protein 3; delta3; drosophila Delta homolog 3
UniProt Protein Name
Delta-like protein 3
Protein Family
UniProt Gene Name
DLL3
UniProt Synonym Gene Names
Delta3
UniProt Entry Name
DLL3_HUMAN

NCBI Description

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: integral to membrane

Molecular Function: Notch binding

Biological Process: compartment specification; paraxial mesoderm development; Notch signaling pathway; somitogenesis; skeletal development; negative regulation of neurogenesis

Disease: Spondylocostal Dysostosis 1, Autosomal Recessive

Research Articles on DLL3

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Product Notes

The DLL3 dll3 (Catalog #AAA601745) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DLL3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Western Blot: 1ug/ml using recombinant human DLL3 Optimal dilutions to be determined by the researcher. Other applications not tested. Researchers should empirically determine the suitability of the DLL3 dll3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DLL3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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