ELISA (EIA)
(Sandwich ELISA analysis of human CXCL9 using Mouse anti Human CXCL9 (MBS226141) as a capture reagent and biotinylated Mouse anti Human CXCL9 as a detection reagent with purified recombinant CXCL9 as the antigen. Detection was performed using HR)
Mouse anti-Human CXCL9 Monoclonal Antibody | anti-CXCL9 antibody
Mouse anti Human CXCL9
0.09% Sodium Azide (NaN3)
Purified IgG - liquid
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
ELISA (EIA)
(Sandwich ELISA analysis of human CXCL9 using Mouse anti Human CXCL9 (MBS226141) as a capture reagent and biotinylated Mouse anti Human CXCL9 as a detection reagent with purified recombinant CXCL9 as the antigen. Detection was performed using HR)
ELISA (EIA)
(Sandwich ELISA analysis of human CXCL9 using Mouse anti Human CXCL9 (MBS226141) as a capture reagent and biotinylated Mouse anti Human CXCL9 as a detection reagent with purified recombinant CXCL9 as the antigen. Detection was performed using HR)
Synthesis of CXCL9 is induced by IFN-gamma and it mediates lymphoytic infiltration to focal sites and inhibits tumor growth (Tokunaga et al. 2018). CXCL9 is not detectable under physiological conditions in non-lymphoid tissues. However in response to inflammation or injury, IFN-gamma induces CXCL9 production in blood and tissue cells. CXCL9 is a ligand of CXCR3, a classic 7 transmembrane G protein coupled receptor. Upon binding to this receptor the signaling pathways Src, PI3k and MAPK can be activated (Koper et al. 2018).
The purified Mouse anti Human CXCL9 antibody, clone C04-3E4 can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CXCL9 antibody, clone C09-9H7 as the detection antibody.
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]
Uniprot Description
CXCL9: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular space; extracellular region; external side of plasma membrane
Molecular Function: protein binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity
Biological Process: defense response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; positive regulation of myoblast differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; cellular defense response; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; defense response to virus
Research Articles on CXCL9
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Product Notes
The CXCL9 cxcl9 (Catalog #AAA226141) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Human CXCL9 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CXCL9 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1.0ug/ml. Researchers should empirically determine the suitability of the CXCL9 cxcl9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCL9, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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