Rabbit anti-Mouse CTSE  Monoclonal Antibody | anti-CTSE  antibody

Rabbit anti Mouse CTSE  Monoclonal Antibody

Cat. Num. AAA2544610

• Gene Names: Ctse; CE; CatE; A430072O03Rik; C920004C08Rik
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CTSE ; Monoclonal Antibody; Rabbit anti Mouse CTSE Monoclonal Antibody; anti-CTSE antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 397

• Applicable Applications for anti-CTSE antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CTSE. The detection limit for Mouse CTSE is approximately 0.0049 ng/well.
• Immunogen: Recombinant Mouse Cathepsin E/CTSE protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CTSE  antibody

Cathepsin E Protein (CTSE Protein) is a member of the peptidase C1 family that is a gastric aspartic protease that functions as a disulfide-linked homodimer. Cathepsin E Protein (CTSE Protein) is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC classII pathway which however does not appear to be involved in the digestion of dietary protein. The protein has a specificity similar to that of pepsin and pepsin. Cathepsin E Protein (CTSE Protein) is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach and also been found in more than half of the gastric cancers. It appears, therefore, to be an oncofetal antigen.

NCBI and Uniprot Product Information

• NCBI GI #: 71059833
• NCBI GeneID: 13034
• UniProt Accession #: P70269; O35647; Q3UKT5; Q4FK00
• Molecular Weight: 42,938 Da
• NCBI Official Full Name: Ctse
• NCBI Official Synonym Full Names: cathepsin E
• NCBI Official Symbol: Ctse
• NCBI Official Synonym Symbols: CE; CatE; A430072O03Rik; C920004C08Rik
• NCBI Protein Information: cathepsin E
• UniProt Protein Name: Cathepsin E
• UniProt Gene Name: Ctse
• UniProt Entry Name: CATE_MOUSE

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]

Uniprot Description

CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.34; Protease

Cellular Component: endosome

Molecular Function: aspartic-type endopeptidase activity; protein homodimerization activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; protein autoprocessing; protein catabolic process