Immunohistochemistry (IHC)
(Anti-CRTC1 / MECT1 / TORC1 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Mouse anti-Human CRTC1 / MECT1 / TORC1 Monoclonal Antibody | anti-CRTC1 antibody
Mouse Monoclonal [clone 1B5] (IgG1) to Human CRTC1 / MECT1 / TORC1
Immunohistochemistry (IHC)
(Anti-CRTC1 / MECT1 / TORC1 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-CRTC1 / MECT1 / TORC1 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunofluorescence (IF)
(Immunofluorescence of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.)
Immunofluorescence (IF)
(Immunofluorescence of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.)
Flow Cytometry (FC/FACS)
(Flow cytometry of K562 cells using CRTC1 mouse mAb (green) and negative control (purple).)
Flow Cytometry (FC/FACS)
(Flow cytometry of K562 cells using CRTC1 mouse mAb (green) and negative control (purple).)
Western Blot (WB)
(Western blot of CRTC1 mouse mAb against CRTC1(AA: 1-353)-hIgGFc transfected HEK293 cell lysate.)
Western Blot (WB)
(Western blot of CRTC1 mouse mAb against CRTC1(AA: 1-353)-hIgGFc transfected HEK293 cell lysate.)
NCBI and Uniprot Product Information
Uniprot Description
TORC1: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; cAMP response element binding protein binding
Biological Process: transcription, DNA-dependent; viral reproduction; membrane hyperpolarization; rhythmic process; activation of CREB transcription factor; positive regulation of transcription from RNA polymerase II promoter; memory; protein homotetramerization; entrainment of circadian clock by photoperiod
Research Articles on CRTC1
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Product Notes
The CRTC1 crtc1 (Catalog #AAA249194) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone 1B5] (IgG1) to Human CRTC1 / MECT1 / TORC1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CRTC1 / MECT1 / TORC1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA). ELISA (1:10000), Flo (1:200 - 1:400), ICC (1:200 - 1:1000), IF (1:1000), IHC (1:50), WB (1:500 - 1:2000). Researchers should empirically determine the suitability of the CRTC1 crtc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRTC1 / MECT1 / TORC1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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