Mouse anti-Human, Mouse TORC1 Monoclonal Antibody | anti-CRTC1 antibody

TORC1 Antibody

Cat. Num. AAA9215365

• Gene Names: CRTC1; MECT1; TORC1; TORC-1; WAMTP1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunocytochemistry
• Synonyms: TORC1; Monoclonal Antibody; TORC1 Antibody; Purified Mouse Monoclonal Antibody (Mab); KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1_HUMAN; FLJ14027; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1.; anti-CRTC1 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Form/Format: ascites
• Sequence Length: 650

• Applicable Applications for anti-CRTC1 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: WB ~~ 1:2000; ICC ~~ 1:200
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of TORC1 in Hela,mouse brain,SW480,COS7,C6 and 3T3 cell lysates using TORC1 mouse mAb (1:2000 diluted).Predicted band size:78KDa.Observed band size:78KDa.)

Immunocytochemistry (ICC)

(Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using TORC1 mouse mAb (dilution 1:200).)

Related Product Information for anti-CRTC1 antibody

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

Product Categories/Family for anti-CRTC1 antibody

Metabolism; Signal Transduction

References

Iourgenko V.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003). Tonon G.,et al.Nat. Genet. 33:208-213(2003). Tonon G.,et al.Nat. Genet. 33:408-408(2003). Ota T.,et al.Nat. Genet. 36:40-45(2004). Grimwood J.,et al.Nature 428:529-535(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 148596988
• NCBI GeneID: 23373
• NCBI Accession #: NP_001091952.1
• NCBI GenBank Nucleotide #: NM_001098482.1
• UniProt Accession #: Q6UUV9; O75114; Q6Y3A3; Q7LDZ2; Q8IUL3; Q8IZ34; Q8IZL1; Q8N6W3; Q96AI8; Q9H801; A6NMG5
• Molecular Weight: 67300
• NCBI Official Full Name: CREB-regulated transcription coactivator 1 isoform 3
• NCBI Official Synonym Full Names: CREB regulated transcription coactivator 1
• NCBI Official Symbol: CRTC1
• NCBI Official Synonym Symbols: MECT1; TORC1; TORC-1; WAMTP1
• NCBI Protein Information: CREB-regulated transcription coactivator 1
• UniProt Protein Name: CREB-regulated transcription coactivator 1
• Protein Family: CREB-regulated transcription coactivator
• UniProt Gene Name: CRTC1
• UniProt Synonym Gene Names: TORC-1; Transducer of CREB protein 1
• UniProt Entry Name: CRTC1_HUMAN

NCBI Description

TORC1: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; cell soma; dendrite; cytoplasm; plasma membrane; synapse; nucleus

Molecular Function: protein binding; cAMP response element binding protein binding

Biological Process: transcription, DNA-dependent; viral reproduction; membrane hyperpolarization; rhythmic process; activation of CREB transcription factor; positive regulation of transcription from RNA polymerase II promoter; memory; protein homotetramerization; entrainment of circadian clock by photoperiod

Uniprot Description

TORC1: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cell soma; cytoplasm; dendrite; nucleoplasm; nucleus; plasma membrane; synapse

Molecular Function: cAMP response element binding protein binding; protein binding

Biological Process: activation of CREB transcription factor; entrainment of circadian clock by photoperiod; membrane hyperpolarization; memory; positive regulation of transcription from RNA polymerase II promoter; protein homotetramerization; rhythmic process; transcription, DNA-dependent; viral reproduction