Rabbit anti-Mouse CRABP2  Monoclonal Antibody | anti-CRABP2  antibody

Rabbit anti Mouse CRABP2  Monoclonal Antibody

Cat. Num. AAA2544603

• Gene Names: CRABP2; RBP6; CRABP-II
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CRABP2 ; Monoclonal Antibody; Rabbit anti Mouse CRABP2 Monoclonal Antibody; anti-CRABP2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 138

• Applicable Applications for anti-CRABP2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CRABP2. The detection limit for Mouse CRABP2 is approximately 0.039 ng/well.
• Immunogen: Recombinant Mouse CRABP2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CRABP2  antibody

Mouse cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema.

NCBI and Uniprot Product Information

• NCBI GI #: 315013542
• NCBI GeneID: 1382
• NCBI GenBank Nucleotide #: NM_001199723.1
• Molecular Weight: 15,693 Da
• NCBI Official Full Name: cellular retinoic acid-binding protein 2
• NCBI Official Synonym Full Names: cellular retinoic acid binding protein 2
• NCBI Official Symbol: CRABP2
• NCBI Official Synonym Symbols: RBP6; CRABP-II
• NCBI Protein Information: cellular retinoic acid-binding protein 2
• UniProt Protein Name: Cellular retinoic acid-binding protein 2
• UniProt Gene Name: CRABP2
• UniProt Synonym Gene Names: CRABP-II
• UniProt Entry Name: RABP2_HUMAN

NCBI Description

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Uniprot Description

CRABP2: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: protein binding; retinoid binding

Biological Process: epidermis development; regulation of transcription, DNA-dependent; signal transduction