Western Blot (WB)
(ING2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ING2 antibody detected the ING2 protein (arrow).)
Rabbit anti-Human ING2 Polyclonal Antibody | anti-ING2 antibody
ING2 Antibody (Center)
Western Blot (WB)
(ING2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ING2 antibody detected the ING2 protein (arrow).)
Western Blot (WB)
(ING2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ING2 antibody detected the ING2 protein (arrow).)
family. Members of the ING family associate with and modulate the
activity of histone acetyltransferase (HAT) and histone deacetylase
(HDAC) complexes and function in DNA repair and apoptosis.
Larrieu, D., et al. EMBO Rep. 10(10):1168-1174(2009)
Kumamoto, K., et al. Int. J. Cancer 125(6):1306-1315(2009)
Borkosky, S.S., et al. J. Cancer Res. Clin. Oncol. 135(5):703-713(2009)
Unoki, M., et al. FEBS Lett. 582(28):3868-3874(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
ING2: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). Belongs to the ING family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: nucleoplasm; Golgi apparatus; CCAAT-binding factor complex; Sin3 complex; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; protein complex binding; chromatin binding; methylated histone residue binding; phosphoinositide binding
Biological Process: transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; chromatin modification; signal transduction; negative regulation of cell proliferation; sperm motility; male meiosis I; regulation of transcription, DNA-dependent; regulation of growth; spermatogenesis; male germ-line stem cell division; spermatid development
Research Articles on ING2
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Product Notes
The ING2 ing2 (Catalog #AAA9211216) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 112-141. The ING2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ING2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ING2 ing2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ING2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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