Mouse anti-Human Clara Cell Protein Monoclonal Antibody

Clara Cell Protein (CC16, CC10, Uteroglobin, Urinary Protein 1, Clara Cell Secretory Protein, Secretoglobin Family 1A Member 1, CCPBP, Clara Cells 10kD Secretory Protein, CC10, UP1, Clara Cell Phospholipid-binding Protein, SCGB1A1, CCSP, UGB)

Cat. Num. AAA648554

• Reactivity: Human
• Applications: ELISA, Western Blot, Flow Cytometry, Functional Assay
• Purity: Purified
• Synonyms: Clara Cell Protein; Monoclonal Antibody; Clara Cell Protein (CC16; CC10; Uteroglobin; Urinary Protein 1; Clara Cell Secretory Protein; Secretoglobin Family 1A Member 1; CCPBP; Clara Cells 10kD Secretory Protein; UP1; Clara Cell Phospholipid-binding Protein; SCGB1A1; CCSP; UGB); Anti -Clara Cell Protein (CC16; anti-Clara Cell Protein antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 13B183
• Specificity: Human
• Purity/Purification: Purified
• Form/Format: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

• Applicable Applications for anti-Clara Cell Protein antibody: ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
• Application Notes: Western Blot: 1:500-1:2000, Flow Cytometry: 1:200-1:400, ELISA: 1:10000
• Immunogen: Purified recombinant fragment of human SCGB1A1 (AA: 26-91) expressed in E. coli.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of human SCGB1A1 recombinant protein using MBS648554. (Expected MW is 33.4kD))

Western Blot (WB)

(Western Blot analysis in HEK293 (lane 1) and SCGB1A1 (aa26-91)-hIgGFc transfected HEK293 (lane 2) cell lysate using MBS648554.)

Testing Data

Flow Cytometry (FC/FACS)

(Flow Cytometric analysis of A549 cells using MBS648554 (green) and negative control (red).)

Related Product Information for anti-Clara Cell Protein antibody

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma.

Clara cells are dome-shaped cells with short microvilli found in the small airways (bronchioles) of the lungs.[1] Clara cells are found in the ciliated simple epithelium. These cells may secrete glycosaminoglycans to protect the bronchiole lining. Bronchiolar cells gradually increase in number as the number of goblet cells decrease. They are also known as "bronchiolar exocrine cells".[2] One of the main functions of Clara cells is to protect the bronchiolar epithelium. They do this by secreting a small variety of products, including Clara cell secretory protein (CCSP) and a solution similar to the component of the lung surfactant. They are also responsible for detoxifying harmful substances inhaled into the lungs. Clara cells accomplish this with cytochrome P450 enzymes found in their smooth endoplasmic reticulum. Clara cells also act as a stem cell and multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.[5][edit]Mechanism

Product Categories/Family for anti-Clara Cell Protein antibody

Antibodies; Abs to Secretoglobin

NCBI and Uniprot Product Information

• NCBI GI #: 157830545
• NCBI Official Full Name: Chain A, Refined Structure Of Rat Clara Cell 17 Kda Protein At 3.0 Angstroms Resolution