Rabbit anti-Mouse, Rat Clara Cell Protein Polyclonal Antibody

Clara Cell Protein (CC16, CC10, Uteroglobin, Urinary Protein 1, Clara Cell Secretory Protein, CCSP)

Cat. Num. AAA616284

• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Serum; Serum
• Synonyms: Clara Cell Protein; Polyclonal Antibody; Clara Cell Protein (CC16; CC10; Uteroglobin; Urinary Protein 1; Clara Cell Secretory Protein; CCSP); Anti -Clara Cell Protein (CC16; anti-Clara Cell Protein antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Clara Cell Secretory Protein, Mr 10kD.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid, 0.05% sodium azide, 30% glycerol

• Applicable Applications for anti-Clara Cell Protein antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry and Western Blot.; Dilution: Immunohistochemistry: 1:2000 dilution detected CCSP in paraffin-embedded mouse lung sections. Paraffin-embedded adult mouse lung sections were stained with C5828-03. Proteins were visualized using a biotinylated goat anti-rabbit secondary antibody and an ABC detection system.; Western Blot: Reported to detect CCSP in mouse lung nuclear extracts.
• Immunogen: Synthetic peptide corresponding to aa45-68 of mouse Clara Cell Secretory Protein, conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(IHC: CCSP was detected in paraffin-embedded mouse lung sections using MBS616284.)

Related Product Information for anti-Clara Cell Protein antibody

Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as a number of other immunomodulatory features, including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.

Product Categories/Family for anti-Clara Cell Protein antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 157830545
• NCBI Official Full Name: Chain A, Refined Structure Of Rat Clara Cell 17 Kda Protein At 3.0 Angstroms Resolution