Mouse anti-Human CD62E Monoclonal Antibody | anti-CD62E antibody
Mouse Anti-Human CD62E Monoclonal Antibody, Azide Free Clone B-S3
Reactivity
Human
Applications
ELISA
Synonyms
CD62E; Monoclonal Antibody; Mouse Anti-Human CD62E Monoclonal Antibody; Azide Free Clone B-S3; ELAM-1; E-Selectin; anti-CD62E antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1 Kappa light chain
Clone Number
B-S3
Specificity
Recognizes the Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1), E-selectin, a 97 kDa protein
Form/Format
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free.
Applicable Applications for anti-CD62E antibody
ELISA
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunization
Activated human endothelial cells
Preparation and Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Related Product Information for anti-CD62E antibody
E-selectin (CD62E) is a 115 kDa glycoprotein, expressed only on endothelial cells after activation with interleukin-1 (IL-1), tumor necrosis factor-α (TNFα), or bacterial lipopolysaccharides. After stimulation of the endothelial cells, the newly synthesized E-selectin is rapidly detected, with maximum surface expression after 3-6 h and return to basal levels within 24 h. This rapid down-regulation, although poorly understood, has been explained by the release of a soluble form of E-selectin and the internalization of the molecule. This regulation of E-selectin expression could be crucial for controlling leukocyte accumulation in inflammatory responses. Several E-selectin ligands have been identified on leukocytes, but have not yet been cloned. Monoclonal antibodies (mAbs) specific for E selectin have been shown to inhibit leukocyte transmigration. It has been suggested that leukocyte binding to E-selectin on activated endothelium positively regulates CD11b (Mac-1) on leukocytes and induces increased adhesion by the ICAM-1 / Mac-1 interaction.
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Product Notes
The CD62E (Catalog #AAA335102) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human CD62E Monoclonal Antibody, Azide Free Clone B-S3 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD62E can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the CD62E for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD62E, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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