Testing Data
(A typical staining pattern with the B-A35 monoclonal antibody of monocytes)
Mouse anti-Human CD141 Monoclonal Antibody | anti-CD141 antibody
Mouse Anti-Human CD141 Monoclonal Antibody, Azide Free Clone B-A35
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, ELISA
Purity
Ion exchange chromatography
Synonyms
CD141; Monoclonal Antibody; Mouse Anti-Human CD141 Monoclonal Antibody; Azide Free Clone B-A35; Thrombomodulin; anti-CD141 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1 Kappa light chain
Clone Number
B-A35
Specificity
Recognises thrombomodulin (TM), a 105 kDa protein
Purity/Purification
Ion exchange chromatography
Form/Format
Azide free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
Applicable Applications for anti-CD141 antibody
Flow Cytometry (FC/FACS), ELISA (EIA)
Antigen
CD141 / Thrombomodulin
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
TF1 cell line
Preparation and Storage
Store at +2-8°C. For longer storage, freeze aliquots.
Testing Data
(A typical staining pattern with the B-A35 monoclonal antibody of monocytes)
Testing Data
(A typical staining pattern with the B-A35 monoclonal antibody of monocytes)
Related Product Information for anti-CD141 antibody
CD141 , also known as Thrombomodulin or BDC-A is an transmembrane protein expressed predominantly on the surface of vascular endothelial cells, but also on other cell types such as macrophages, monocytes, subpopulation of myeloid dendritic cells and keratinocytes. Thrombomodulin is a type 1 membrane glycoprotein of 74kDa consisting on a single chain with 6 Epidermal Growth Factor (EGF)-like domains critical for Thrombin and proteine C binding, and four other domains (an N-terminal C-type lectin domain, a highly glycosylated serine/threonine-rich domain, a transmembrane segment, and a short C-terminal cytoplasmic tail. It acts as an important component in the anti-coagulation and fibrinolysis system : cofactor for active thrombin, the thrombomodulin-thrombin complex activates protein C to degrade coagulation factors, inhibiting coagulation and fibrinolysis.
When vascular endothelial cells injury occurs, proteolytic cleavage release multiple fragments of thrombomodulin in circulation, so it represents a good marker for endothelial cell damage in pathologies such as cardiovascular disease, acute coronary syndrome, pulmonary thromboembolism or severe hemorrhage. Thrombomodulin has been described as an anticoagulant effect protein, and its therapeutical potential for preventing deep vein thrombosis and its use in the treatment of disseminated intravascular coagulation is under demonstrated in preliminary data.
More recently, other biological effects beyond anticoagulation have been demonstrated such as an anti-inflammatory , cell adhesion and proliferation regulation It is also demonstrated that thrombomodulin may be able to suppress the metastatic capacity of tumor cells, and hence have a protective role in many types of malignancies.
When vascular endothelial cells injury occurs, proteolytic cleavage release multiple fragments of thrombomodulin in circulation, so it represents a good marker for endothelial cell damage in pathologies such as cardiovascular disease, acute coronary syndrome, pulmonary thromboembolism or severe hemorrhage. Thrombomodulin has been described as an anticoagulant effect protein, and its therapeutical potential for preventing deep vein thrombosis and its use in the treatment of disseminated intravascular coagulation is under demonstrated in preliminary data.
More recently, other biological effects beyond anticoagulation have been demonstrated such as an anti-inflammatory , cell adhesion and proliferation regulation It is also demonstrated that thrombomodulin may be able to suppress the metastatic capacity of tumor cells, and hence have a protective role in many types of malignancies.
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Product Notes
The CD141 (Catalog #AAA335123) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human CD141 Monoclonal Antibody, Azide Free Clone B-A35 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD141 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), ELISA (EIA). Researchers should empirically determine the suitability of the CD141 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD141, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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