Rat anti-Human CD267 Monoclonal Antibody | anti-CD267 antibody

Anti-Hu CD267 APC

Cat. Num. AAA1800070

• Gene Names: TNFRSF13B; CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: CD267; Monoclonal Antibody; Anti-Hu CD267 APC; TNF receptor superfamily member 13B; RYZN; TACI; CVID2; IGAD2; TNFRSF14B; anti-CD267 antibody

• Host: Rat
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 1A1
• Specificity: The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
• Purity/Purification: The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
• Sequence Length: 293

• Applicable Applications for anti-CD267 antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: QC tested
• Immunogen: CD267-transfected RBL cells
• Conjugation: APC
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Flow Cytometry (FC/FACS)

(Flow cytometry multicolor surface staining of human lymphocytes using anti-human CD267 (1A1) APC (10 ul reagent / 100 ul of peripheral whole blood) and anti-human CD19 (LT19) PE (20 ul reagent / 100 ul of peripheral whole blood) antibody.)

Related Product Information for anti-CD267 antibody

CD267 / TACI (Transmembrane Activator Calcium modulator and cyclophilin ligand Interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency.

NCBI and Uniprot Product Information

• NCBI GI #: 6912694
• NCBI GeneID: 23495
• NCBI Accession #: NP_036584.1
• NCBI GenBank Nucleotide #: NP_036584.1
• UniProt Accession #: O14836
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 13B
• NCBI Official Synonym Full Names: TNF receptor superfamily member 13B
• NCBI Official Symbol: TNFRSF13B
• NCBI Official Synonym Symbols: CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 13B
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 13B
• UniProt Gene Name: TNFRSF13B
• UniProt Synonym Gene Names: TACI

NCBI Description

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF13B: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. Defects in TNFRSF13B are the cause of immunodeficiency common variable type 2 (CVID2). CVID2 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Defects in TNFRSF13B are a cause of immunoglobulin A deficiency 2 (IGAD2). Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: B cell homeostasis; cell surface receptor linked signal transduction; hemopoietic progenitor cell differentiation; negative regulation of B cell proliferation; tumor necrosis factor-mediated signaling pathway

Disease: Immunodeficiency, Common Variable, 2; Immunoglobulin A Deficiency 2