Flow Cytometry (FC/FACS)
(Flow cytometry (surface staining) of CD140b / PDGF-RB in human CD140b / PDGF-RB stable transfectants with anti-CD140b (18A2) purified GAM-APC.)
Mouse anti-Human CD140b Monoclonal Antibody | anti-CD140b antibody
Anti-Hu CD140b Purified
Gene Names
PDGFRB; IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD140b; Monoclonal Antibody; Anti-Hu CD140b Purified; platelet derived growth factor receptor beta; PDGFRB; PDGF receptor beta; PDGFR1; anti-CD140b antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
18A2
Specificity
The monoclonal antibody 18A2 recognizes an extracellular epitope of CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
777
Applicable Applications for anti-CD140b antibody
Flow Cytometry (FC/FACS), Immunocytochemistry (ICC)
Application Notes
FC/FACS: QC tested
Immunogen
CD140b-transfected NIH 3T3 cells
Preparation and Storage
Store at 2-8 degree C.
Flow Cytometry (FC/FACS)
(Flow cytometry (surface staining) of CD140b / PDGF-RB in human CD140b / PDGF-RB stable transfectants with anti-CD140b (18A2) purified GAM-APC.)
Flow Cytometry (FC/FACS)
(Flow cytometry (surface staining) of CD140b / PDGF-RB in human CD140b / PDGF-RB stable transfectants with anti-CD140b (18A2) purified GAM-APC.)
Related Product Information for anti-CD140b antibody
CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Platelet-derived growth factor receptor beta variant
NCBI Official Synonym Full Names
platelet derived growth factor receptor beta
NCBI Official Symbol
PDGFRB
NCBI Official Synonym Symbols
IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1
NCBI Protein Information
platelet-derived growth factor receptor beta
NCBI Description
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
Research Articles on CD140b
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Product Notes
The CD140b (Catalog #AAA1800066) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD140b Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD140b can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunocytochemistry (ICC). FC/FACS: QC tested. Researchers should empirically determine the suitability of the CD140b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD140b, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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