Testing Data
Mouse anti-Rat CD134 Monoclonal Antibody | anti-CD134 antibody
Anti-Rat CD134, Purified (Clone OX40) (mouse IgG2b)
Gene Names
TNFRSF4; OX40; ACT35; CD134; TXGP1L
Reactivity
Rat
Applications
Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Purified Ig buffered in PBS and 0.02% NaN3. (Purified from ascites fluid via Protein G Chromatography).
Synonyms
CD134; Monoclonal Antibody; Anti-Rat CD134; Purified (Clone OX40) (mouse IgG2b); Anti-Rat CD134 (OX40) Monoclonal Antibody; anti-CD134 antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Isotype
Mouse IgG2b
Clone Number
OX40
Specificity
CD134 (Rat CD134 (OX40))
Purity/Purification
Purified Ig buffered in PBS and 0.02% NaN3. (Purified from ascites fluid via Protein G Chromatography).
Form/Format
Purified
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
277
Applicable Applications for anti-CD134 antibody
Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Immunogen
Phytohaemagglutinin-activated rat lymph node cells
Donor
Mouse spleen
Fusion Partner
NS1/1.Ag4.1 cell line
Presentation
Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography).
Preparation and Storage
For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin, FITC), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
Testing Data
Testing Data
Related Product Information for anti-CD134 antibody
anti-rat CD134 (OX40) monoclonal antibody recognizes an antigen related to NGF on activated T cells that also express CD4. It detects a single chain of 51-55 kDa (unreduced) and 47-51 kDa (reduced) in immunoprecipitation assay1. OX40/OX40L interaction has been shown to deliver a potent costimulatory signal to the CD4+ T cell4. While mouse OX40 shows 90% homology with rat, it is expressed on both CD4+ and CD8+ cells in the mouse. This antibody was shown to block binding of OX40L to OX403. This antibody is suitable for use in flow cytometry and immunohistochemistry (frozen sections). It has also been reported as suitable for use in protein purification5.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
29,341 Da
NCBI Official Full Name
CD134 antigen
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 4
NCBI Official Symbol
TNFRSF4
NCBI Official Synonym Symbols
OX40; ACT35; CD134; TXGP1L
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
UniProt Gene Name
TNFRSF4
UniProt Synonym Gene Names
TXGP1L
UniProt Entry Name
TNR4_HUMAN
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Receptor for TNFSF4/OX40L/GP34.
Subunit structure: Interacts with TRAF2, TRAF3 and TRAF5. Ref.7 Ref.8
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence similarities: Contains 4 TNFR-Cys repeats.
Sequence caution: The sequence AAB33944.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on CD134
Similar Products
Product Notes
The CD134 tnfrsf4 (Catalog #AAA520049) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Rat CD134, Purified (Clone OX40) (mouse IgG2b) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD134 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD134 tnfrsf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD134, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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