CD134 recombinant protein

Recombinant Human CD134 protein, C-His Tag

Cat. Num. AAA1560579

• Gene Names: TNFRSF4; OX40; ACT35; CD134; IMD16; TXGP1L
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD134; Recombinant Human CD134 protein; C-His Tag; TNFRSF4; OX40; OX40L receptor; ACT35; TXGP1L; CD134 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human TNFRSF4 (Met1-Ala216) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

SDS-Page

Related Product Information for CD134 recombinant protein

Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40/TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4 is receptor for TNFSF4/OX40L/GP34 and can interacts with TRAF2, TRAF3 and TRAF5.

Product Categories/Family for CD134 recombinant protein

Protein

References

Sallman, McLemore, Aldrich, Komrokji, McGraw, Dhawan, Geyer, Hou, Eksioglu, Sullivan, Warren, MacBeth, Meggendorfer, Haferlach, Boettcher, Ebert, Al-Ali, Lancet, Cleveland, Padron, List (2020) TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype Blood ()

NCBI and Uniprot Product Information

• NCBI GI #: 1171933
• NCBI GeneID: 7293
• UniProt Accession #: P43489; Q13663; Q2M312; Q5T7M0
• Molecular Weight: 277
• NCBI Official Full Name: Tumor necrosis factor receptor superfamily member 4
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 4
• NCBI Official Symbol: TNFRSF4
• NCBI Official Synonym Symbols: OX40; ACT35; CD134; IMD16; TXGP1L
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 4; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 r
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 4
• UniProt Gene Name: TNFRSF4
• UniProt Synonym Gene Names: TXGP1L
• UniProt Entry Name: TNR4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF4: Receptor for TNFSF4/OX40L/GP34.

Protein type: Apoptosis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: T cell proliferation; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; inflammatory response; regulation of protein kinase activity

Disease: Immunodeficiency 16