Mouse anti-Human BUB1B Monoclonal Antibody | anti-BUB1B antibody
Anti-BUB1B
Reactivity
Human
Applications
ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
Purity
Protein A chromatography
Synonyms
BUB1B; Monoclonal Antibody; Anti-BUB1B; anti-BUB1B antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse, IgG1
Specificity
Recognizes the human BUBR1 Kinase protein
Purity/Purification
Protein A chromatography
Form/Format
0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH7.2 + 0.01% (w/v) Sodium Azide
Applicable Applications for anti-BUB1B antibody
ELISA (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
Immunogen
The antibody was produced against synthesized peptide corresponding to amino acid residues 1-350 of human BUBR1 Kinase protein.
Preparation and Storage
1 year at -20 degree C from date of shipment
Related Product Information for anti-BUB1B antibody
BUB1B or budding uninhibited by benzimidazoles 1 homolog beta is involved in spindle checkpoint function and has been localized to the kinetochore. BUB1B plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation (1). BUB1B links the regulation of chromosome-spindle attachment to mitotic checkpoint signaling (2). BUB1B expression during the spindle checkpoint is dependent on residual BUB1B expression and impaired spindle checkpoint function has been found in many forms of cancer. BUB1B is essential for early embryonic development and normal hematopoiesis.
Product Categories/Family for anti-BUB1B antibody
References
1. Rio Frio. Et.al: Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. New Eng. J. Med. 363: 2628-2637, 2010.
2. Lampson, M. A., Kapoor. et.al: The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nature Cell Biol. 7: 93-98, 2005.
2. Lampson, M. A., Kapoor. et.al: The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nature Cell Biol. 7: 93-98, 2005.
Similar Products
Product Notes
The BUB1B (Catalog #AAA515867) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-BUB1B reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BUB1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the BUB1B for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BUB1B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
