Western Blot (WB)
(Western blot detection of ATIC in various tissues and cell lysates using ATIC mouse mAb (1:1000 diluted).Predicted band size:64KDa.Observed band size:64KDa.)
Mouse anti-Human, Mouse ATIC Monoclonal Antibody | anti-ATIC antibody
ATIC Antibody
Western Blot (WB)
(Western blot detection of ATIC in various tissues and cell lysates using ATIC mouse mAb (1:1000 diluted).Predicted band size:64KDa.Observed band size:64KDa.)
Western Blot (WB)
(Western blot detection of ATIC in various tissues and cell lysates using ATIC mouse mAb (1:1000 diluted).Predicted band size:64KDa.Observed band size:64KDa.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
Uniprot Description
ATIC: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR). A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA- ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. Belongs to the PurH family.
Protein type: Methyltransferase; Cofactor and Vitamin Metabolism - one carbon pool by folate; Nucleotide Metabolism - purine; EC 2.1.2.3; EC 3.5.4.10; Hydrolase
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: membrane; mitochondrion; cytosol
Molecular Function: protein homodimerization activity; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity
Biological Process: purine ribonucleoside monophosphate biosynthetic process; tetrahydrofolate biosynthetic process; organ regeneration; response to inorganic substance; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; dihydrofolate metabolic process; nucleoside metabolic process; cerebellum development; cerebral cortex development; purine base metabolic process; 'de novo' IMP biosynthetic process
Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency
Research Articles on ATIC
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Product Notes
The ATIC atic (Catalog #AAA9215449) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ATIC Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ATIC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB ~~ 1:1000. Researchers should empirically determine the suitability of the ATIC atic for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATIC, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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