Western Blot (WB)
(Western Blot detection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted).)
Mouse ATIC Monoclonal Antibody | anti-ATIC antibody
ATIC Monoclonal Antibody
Gene Names
ATIC; PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
ATIC; Monoclonal Antibody; ATIC Monoclonal Antibody; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase2.IMP cyclohydrolase; IMP synthase Inosinicase; PURH; AICAR; AICARFT; IMPCHASE; anti-ATIC antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Specificity
This antibody detects endogenous levels of ATIC and does not cross-react with related proteins
Purity/Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
592
Applicable Applications for anti-ATIC antibody
Western Blot (WB)
Application Notes
WB: 1:1000
Immunogen
Recombinant full length Human ATIC.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot detection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted).)
Western Blot (WB)
(Western Blot detection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted).)
Related Product Information for anti-ATIC antibody
The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Predicted Band Size: 64KDa
Observed Band Size: 64KDa
Observed Band Size: 64KDa
NCBI Official Full Name
bifunctional purine biosynthesis protein PURH
NCBI Official Synonym Full Names
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
NCBI Official Symbol
ATIC
NCBI Official Synonym Symbols
PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p
NCBI Protein Information
bifunctional purine biosynthesis protein PURH
UniProt Protein Name
Bifunctional purine biosynthesis protein PURH
UniProt Gene Name
ATIC
UniProt Synonym Gene Names
PURH
UniProt Entry Name
PUR9_HUMAN
NCBI Description
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
Research Articles on ATIC
Similar Products
Product Notes
The ATIC atic (Catalog #AAA3014236) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ATIC Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ATIC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the ATIC atic for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATIC, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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