Mouse Aggregation Factor, Geodia cydonium Monoclonal Antibody

Aggregation Factor, Geodia cydonium

Cat. Num. AAA605823

• Applications: ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography
• Synonyms: Aggregation Factor; Geodia cydonium; Monoclonal Antibody; Anti -Aggregation Factor; anti-Aggregation Factor; Geodia cydonium antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 1D2
• Specificity: Specific for the 140kD polypeptide in the aggregation factor of Geodia cydonium
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography
• Form/Format: Supplied as a lyophilized powder in Tris, pH 7.4.

• Applicable Applications for anti-Aggregation Factor, Geodia cydonium antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry.; Dilution: ELISA: 1:1000; Western Blot: 1:1000
• Immunogen: 140kD polypeptide in the aggregation factor (AF) of Geodia cydonium
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

(a: SDS-PAGE. Size-separated proteins of enriched sponge AF. b: The proteins in AF fraction were transferred to Immobilon sheets, and incubated with MBS605823.)

Product Categories/Family for anti-Aggregation Factor, Geodia cydonium antibody

Antibodies; Abs to Aggregation Factor

NCBI and Uniprot Product Information

• NCBI GI #: 113975
• NCBI Official Full Name: Annexin A1

Uniprot Description

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (). Displays Ca2+-dependent binding to phospholipid membranes (). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton ().