Mouse anti-Human ADAMTSL-1 Monoclonal Antibody | anti-ADAMTSL1 antibody

ADAMTSL-1 (Punctin, Aggrecanase I, A Disintegrin And Metalloproteinase with ThromboSpondin-3 motif)

Cat. Num. AAA608243

• Gene Names: ADAMTSL1; C9orf94; PUNCTIN; ADAMTSR1; FLJ35283; FLJ41032; FLJ46891; MGC40193; ADAMTSL-1; MGC118803; MGC118805; DKFZp686L03130
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: ADAMTSL-1; Monoclonal Antibody; ADAMTSL-1 (Punctin; Aggrecanase I; A Disintegrin And Metalloproteinase with ThromboSpondin-3 motif); Anti -ADAMTSL-1 (Punctin; anti-ADAMTSL1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 9H43
• Specificity: Recognizes human ADAMTSL-1.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS. Reconstitute with 40-50% glycerol, PBS.

• Applicable Applications for anti-ADAMTSL1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunoprecipitation.; Dilution: ELISA: 0.5-1.0ug/ml; Western Blot: 1-2ug/ml; Immunoprecipitation: 25ug/ml
• Immunogen: NS0-derived, recombinant human ADAMTSL-1; aa 29 -525.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-ADAMTSL1 antibody

ADAMTSL-1, also known as Punctin, is a secreted glycoprotein resembling members of the ADAMTS family although it lacks the propeptide region and the metalloproteinase and disintegrin-like domains. ADAMTSL-1 is expressed in adult skeletal muscle and may have important functions in the extracellular matrix. Alternative splicing of the ADAMTSL-1 transcript results in three isoforms. Isoform1 is the longest and contains the entire isoform 2. Isoform 3 has the same sequence as isoforms 1 and 2 until residue 361, but a unique C-terminal end of 78 amino acids.

Product Categories/Family for anti-ADAMTSL1 antibody

Antibodies; Abs to Matrix Metalloproteinases

NCBI and Uniprot Product Information

• NCBI GI #: 154275767
• NCBI GeneID: 92949
• NCBI Accession #: NP_001035362.3
• NCBI GenBank Nucleotide #: NM_001040272.5
• UniProt Accession #: Q8N6G6; Q496M6; Q496M8; Q5T708; Q5VZT8; Q8NAI9; Q96RW4; Q9BXY3; A6PVN1; A8K7E1; Q6MZQ3
• Molecular Weight: 193,409 Da
• NCBI Official Full Name: ADAMTS-like protein 1 isoform 4
• NCBI Official Synonym Full Names: ADAMTS-like 1
• NCBI Official Symbol: ADAMTSL1
• NCBI Official Synonym Symbols: C9orf94; PUNCTIN; ADAMTSR1; FLJ35283; FLJ41032; FLJ46891; MGC40193; ADAMTSL-1; MGC118803; MGC118805; DKFZp686L03130
• NCBI Protein Information: ADAMTS-like protein 1; punctin-1; OTTHUMP00000021085; OTTHUMP00000021086; OTTHUMP00000021088; OTTHUMP00000239538; ADAM-TS related protein 1
• UniProt Protein Name: ADAMTS-like protein 1
• Protein Family: ADAMTS-like protein
• UniProt Gene Name: ADAMTSL1
• UniProt Synonym Gene Names: ADAMTSR1; C9orf94
• UniProt Entry Name: ATL1_HUMAN

NCBI Description

This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq]

Uniprot Description

ADAMTSL1: a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p21.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen

Molecular Function: zinc ion binding; metallopeptidase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; post-translational protein modification; proteolysis