4-1BB recombinant antibody
Anti-4-1BB [LOB12.3]
Gene Names
Tnfrsf9; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Purity
Protein A Affinity Purified
Synonyms
4-1BB; Monoclonal Recombinant Antibody; Anti-4-1BB [LOB12.3]; CD137; TNFRSF9; 41BB; 4-1BBL Ligand; Tumor necrosis factor superfamily member 9; TNF receptor superfamily member 9; LOB 12.3; LOB123; LOB12.3; 4-1BB recombinant antibody
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat IgG2a, Kappa
Clone Number
LOB12.3
Specificity
This antibody binds to mouse 4-1BB (CD137).
Purity/Purification
Protein A Affinity Purified
Concentration
1 mg/ml (varies by lot)
Sequence Length
256
Applicable Applications for 4-1BB recombinant antibody
Flow Cytometry (FC/FACS), Activate
Application Notes
This antibody can be used to detect mouse 4-1BB (CD137). In its original rat IgG1 format, this antibody had agonistic effect and prolonged survival of mice bearing CT26 or A31 tumors. In the original publication another clone LOB12 disclosed which has a rat IgG2a isotype. This has led to some confusion in the literature with regards to the original isotype of LOB12 and LOB12.3. We offer this antibody in both formats as well as murine versions so that researchers may choose the isotype most appropriate for their assays.
Immunogen
This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
Buffer Composition
PBS only with 0.02% Proclin 300.
Chimeric Use Statement
This reformatted rat antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Labeled Substance
None
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Related Product Information for 4-1BB recombinant antibody
Recombinant monoclonal antibody to 4-1BB. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the hybridoma LOB12.3.
This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
Product Categories/Family for 4-1BB recombinant antibody
References
Taraban. Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol. 2002 Dec; 32(12):3617-27 PMID:12516549
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,598 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 9 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol
Tnfrsf9
NCBI Official Synonym Symbols
ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
NCBI Protein Information
tumor necrosis factor receptor superfamily member 9
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 9
UniProt Gene Name
Tnfrsf9
UniProt Synonym Gene Names
Cd137; Ila; Ly63
Uniprot Description
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Research Articles on 4-1BB
Similar Products
Product Notes
The 4-1BB tnfrsf9 (Catalog #AAA488380) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-4-1BB [LOB12.3] reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's 4-1BB can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Activate. This antibody can be used to detect mouse 4-1BB (CD137). In its original rat IgG1 format, this antibody had agonistic effect and prolonged survival of mice bearing CT26 or A31 tumors. In the original publication another clone LOB12 disclosed which has a rat IgG2a isotype. This has led to some confusion in the literature with regards to the original isotype of LOB12 and LOB12.3. We offer this antibody in both formats as well as murine versions so that researchers may choose the isotype most appropriate for their assays. Researchers should empirically determine the suitability of the 4-1BB tnfrsf9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "4-1BB, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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