Mitochondrial intermembrane space import and assembly protein 40 (mia40) Recombinant Protein | tim40 recombinant protein

Recombinant Schizosaccharomyces pombe Mitochondrial intermembrane space import and assembly protein 40 (mia40)

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mitochondrial intermembrane space import and assembly protein 40 (mia40); Recombinant Schizosaccharomyces pombe Mitochondrial intermembrane space import and assembly protein 40 (mia40); Recombinant Mitochondrial intermembrane space import and assembly protein 40 (mia40); Mitochondrial intermembrane space import and assembly protein 40; Mitochondrial import inner membrane translocase TIM40; tim40 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 62-313
• Sequence: AASLTAGYLLGKNTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKSEPKGMECLDKFQAMQACFQKHPEIYQDMVGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEI
• Sequence Length: 313

• Species: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 19114228
• NCBI GeneID: 2542760
• NCBI Accession #: NP_593316.1
• NCBI GenBank Nucleotide #: NM_001018747.2
• UniProt Accession #: P87059
• Molecular Weight: 34,915 Da
• NCBI Official Full Name: TIM22 inner membrane protein import complex subunit Tim40 (predicted)
• NCBI Official Symbol: tim40
• NCBI Protein Information: TIM22 inner membrane protein import complex subunit Tim40 (predicted)
• UniProt Protein Name: Mitochondrial intermembrane space import and assembly protein 40
• UniProt Gene Name: mia40
• UniProt Synonym Gene Names: tim40
• UniProt Entry Name: MIA40_SCHPO

Uniprot Description

Function: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS

By similarity.

Cofactor: Copper or zinc

By similarity.

Subunit structure: Monomer

By similarity.

Subcellular location: Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side

By similarity.

Domain: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria

By similarity.

Sequence similarities: Contains 1 CHCH domain.