METTL21B recombinant protein

Recombinant METTL21B protein

Cat. Num. AAA389256

• Gene Names: METTL21B; FAM119B
• Synonyms: METTL21B; Recombinant METTL21B protein; METTL21B recombinant protein

• Host: Baculovirus
• Form/Format: Recombinant METTL21B protein is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.

• Protein Species: Human
• Tag: DYKDDDDK-Tag
• Notes: This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data this product is shown.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.; Shipping Temp: Dry Ice

SDS-Page

(Recombinant METTL21B protein gel 10% SDS-PAGE gel with Coomassie blue staining MW: 26 kDa Purity: >77%)

Related Product Information for METTL21B recombinant protein

Short Description: Recombinant METTL21B protein was expressed in a baculovirus expression system as the full-length human protein (accession number NP_056248.2) with an N-terminal DYKDDDDK tag. The molecular weight of the protein is 26 kDa.

Background: METTL21B (Methyltransferase-Like Protein 21B), also known as EEF1AKMT3 ((Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 3), is a member of the Family 16 group of methyltransferases. EEF1A is a translation factor which delivers amino-acyl tRNA to the ribosome during translational elongation. In human, EEF1A shows high levels of methylation and has at least six known methylation sites, namely methylation at its N terminus and at lysines 36, 55, 79, 165, and 318. Of these, METTL21B selectively catalyzes the trimethylation of EEF1A at Lys 165. In addition, EEF1AKMT4, METTL13, N6AMT2 (EEF1AKMT1) and METTL10 (EEF1AKMT2) are the methyltransferases for lysines 36, 55, 79 and 318, respectively. EEF1A methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.

Product Categories/Family for METTL21B recombinant protein

Recombinant Proteins; Transcription

NCBI and Uniprot Product Information

• NCBI GI #: 45827721
• NCBI GeneID: 25895
• NCBI Accession #: NP_056248.2
• NCBI GenBank Nucleotide #: NM_015433.2
• UniProt Accession #: Q96AZ1; Q9H749; Q9Y3W2
• Molecular Weight: 24,911 Da
• NCBI Official Full Name: protein-lysine methyltransferase METTL21B isoform a
• NCBI Official Synonym Full Names: methyltransferase like 21B
• NCBI Official Symbol: METTL21B
• NCBI Official Synonym Symbols: FAM119B
• NCBI Protein Information: protein-lysine methyltransferase METTL21B; methyltransferase-like protein 21B; family with sequence similarity 119, member B; hepatocellular carcinoma-associated antigen 557a; hepatocellularcarcinoma-associated antigen HCA557a
• UniProt Protein Name: Protein-lysine methyltransferase METTL21B
• Protein Family: Protein-lysine methyltransferase
• UniProt Gene Name: METTL21B
• UniProt Synonym Gene Names: FAM119B; HCA557A
• UniProt Entry Name: MT21B_HUMAN