DNA replication licensing factor MCM8 (MCM8) Recombinant Protein | MCM8 recombinant protein

Recombinant Human DNA replication licensing factor MCM8 (MCM8) , partial

• Gene Names: MCM8; POF10; C20orf154; dJ967N21.5
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DNA replication licensing factor MCM8 (MCM8); Recombinant Human DNA replication licensing factor MCM8 (MCM8); partial; MCM8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 880

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MCM8 recombinant protein

This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 528078336
• NCBI GeneID: 84515
• NCBI Accession #: NP_001268449.1
• NCBI GenBank Nucleotide #: NM_001281520.1
• UniProt Accession #: Q9UJA3; Q495R4; Q495R6; Q495R7; Q86US4; Q969I5; B2RBG7; D3DW08; E7EQU7
• Molecular Weight: 97,932 Da
• NCBI Official Full Name: DNA helicase MCM8 isoform 1
• NCBI Official Synonym Full Names: minichromosome maintenance 8 homologous recombination repair factor
• NCBI Official Symbol: MCM8
• NCBI Official Synonym Symbols: POF10; C20orf154; dJ967N21.5
• NCBI Protein Information: DNA helicase MCM8
• UniProt Protein Name: DNA helicase MCM8
• Protein Family: DNA helicase
• UniProt Gene Name: MCM8
• UniProt Synonym Gene Names: C20orf154

NCBI Description

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

Uniprot Description

Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G1 phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.