Western Blot (WB)
(IL13 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL13 antibody detected the IL13 protein (arrow).)
Rabbit anti-Human IL13 Polyclonal Antibody | anti-IL13 antibody
IL13 Antibody (C-term)
Western Blot (WB)
(IL13 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL13 antibody detected the IL13 protein (arrow).)
Western Blot (WB)
(IL13 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL13 antibody detected the IL13 protein (arrow).)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of IL13 Antibody (C-term) with MBS9208844 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of IL13 Antibody (C-term) with MBS9208844 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Immunohistochemistry (IHC)
(IL13 Antibody (C-term) (MBS9208844)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IL13 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(IL13 Antibody (C-term) (MBS9208844)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IL13 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
primarily by activated Th2 cells. This cytokine is involved in
several stages of B-cell maturation and differentiation. It
up-regulates CD23 and MHC class II expression, and promotes IgE
isotype switching of B cells. This cytokine down-regulates
macrophage activity, thereby inhibits the production of
pro-inflammatory cytokines and chemokines. This cytokine is found
to be critical to the pathogenesis of allergen-induced asthma but
operates through mechanisms independent of IgE and eosinophils.
This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on
chromosome 5q, with this gene particularly close to IL4. [provided
by RefSeq].
Shi, X., et al. Anat Rec (Hoboken) 293(9):1470-1476(2010)
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Zhao, M., et al. J. Biomed. Biotechnol. 2010, 931018 (2010) :
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Uniprot Description
IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane
Molecular Function: protein binding; interleukin-13 receptor binding; cytokine activity
Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; microglial cell activation; regulation of proton transport; response to lipopolysaccharide; signal transduction; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; cell-cell signaling; positive regulation of B cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; cell motility; negative regulation of NAD(P)H oxidase activity; inflammatory response; positive regulation of macrophage activation
Disease: Asthma, Susceptibility To; Allergic Rhinitis
Research Articles on IL13
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Product Notes
The IL13 il13 (Catalog #AAA9208844) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 118-146. The IL13 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL13 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the IL13 il13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL13, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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