Melanin-Concentrating Hormone Receptor 1 Assay System | MCHR1 assay system
Melanin-Concentrating Hormone Receptor 1 (MCHR1) ACTOne Stable Cell Line
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
Uniprot Description
MCHR1: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: nonmotile primary cilium; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein C-terminus binding; neuropeptide receptor activity; hormone binding; melanin-concentrating hormone receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; neuropeptide signaling pathway; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of calcium ion transport
Research Articles on MCHR1
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Product Notes
The MCHR1 mchr1 (Catalog #AAA433614) is an Assay System and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent human MCHR1 cell-based assay; cell-based high-throughput screening of human MCHR1 inhibitors. Researchers should empirically determine the suitability of the MCHR1 mchr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Melanin-Concentrating Hormone Receptor 1, Assay System" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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