Guanine nucleotide exchange factor DBS (MCF2L) Recombinant Protein | MCF2L recombinant protein

Recombinant Human Guanine nucleotide exchange factor DBS (MCF2L) , partial

• Gene Names: MCF2L; DBS; OST; ARHGEF14
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Guanine nucleotide exchange factor DBS (MCF2L); Recombinant Human Guanine nucleotide exchange factor DBS (MCF2L); partial; MCF2L recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,123

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 339276000
• NCBI GeneID: 23263
• NCBI Accession #: NP_001106203.2
• NCBI GenBank Nucleotide #: NM_001112732.2
• UniProt Accession #: O15068; Q5JU56; Q5VXT1; Q6ZWD4; Q765G8; A2A2X1; A2A2X2; A2A3G6; A2A3G8; B4DHD6; B4DIL6; E9PDN8
• Molecular Weight: 126,111 Da
• NCBI Official Full Name: guanine nucleotide exchange factor DBS isoform a
• NCBI Official Synonym Full Names: MCF.2 cell line derived transforming sequence like
• NCBI Official Symbol: MCF2L
• NCBI Official Synonym Symbols: DBS; OST; ARHGEF14
• NCBI Protein Information: guanine nucleotide exchange factor DBS
• UniProt Protein Name: Guanine nucleotide exchange factor DBS
• Protein Family: Guanine nucleotide exchange factor
• UniProt Gene Name: MCF2L

NCBI Description

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (). Isoform 5 activates CDC42 (PubMed:15157669).