Mannose-binding protein C ELISA Kit | MBL2 elisa kit

Mouse MBL2 PicoKine ELISA Kit

Cat. Num. AAA177543

• Gene Names: Mbl2; MBL; L-MBP; MBL-C; MBP-C
• Reactivity: Mouse. There is no detectable cross-reactivity with other relevant proteins.
• Synonyms: Mannose-binding protein C; Mouse MBL2 PicoKine ELISA Kit; COLEC 1; COLEC1; Collectin-1; HSMBPC; Lectin; mannose-binding; soluble; 2; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C) 2 soluble; Mannose binding lectin (protein C) 2; soluble (opsonic defect); Mannose binding lectin 2 soluble; Mannose binding lectin 2; Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; serum; Mannose-binding lectin; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPB; MBPC; MBPD; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin; mannose-binding lectin (protein C) 2; MBL2 elisa kit

• Reactivity: Mouse. There is no detectable cross-reactivity with other relevant proteins.
• Sequence Length: 244

• Samples: Cell culture supernates, serum and plasma (heparin, EDTA)
• Assay Type: Sandwich
• Sensitivity: <10pg/ml
• Immunogen: NSO, E19-D244
• Intra-Assay Precision: Sample 1: n=16; Mean(ng/ml): 3.2; Standard deviation: 0.157; CV(%): 4.9 Sample 2: n=16; Mean(ng/ml): 8.4; Standard deviation: 0.378; CV(%): 4.5 Sample 3: n=16; Mean(ng/ml): 12.8; Standard deviation: 0.474; CV(%): 3.7
• Inter-Assay Precision: Sample 1: n=24; Mean(ng/ml): 3.6; Standard deviation: 0.23; CV(%): 6.4 Sample 2: n=24; Mean(ng/ml): 8.9; Standard deviation: 0.516; CV(%): 5.8 Sample 3: n=24; Mean(ng/ml): 13.1; Standard deviation: 0.707; CV(%): 5.4
• Assay Range: 312pg/ml-20,000pg/ml
• Preparation and Storage: Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

Typical Testing Data/Standard Curve (for reference only)

(Mouse MBL2 PicoKine ELISA Kit standard curve )

Related Product Information for MBL2 elisa kit

Description: Sandwich ELISA kit of Quantitative Detection for Mouse MBL2
Background: MBL2, also called mannose-binding lectin (protein C) 2, soluble or Mannose-binding lectin (MBL) is a lectin that is instrumental in innate immunity. MBL2 is mapped to chromosome 10q11.2-q21. It belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL2 recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. Binding MBL2 to a micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL2 is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 6754656
• NCBI GeneID: 17195
• NCBI Accession #: NP_034906.1
• NCBI GenBank Nucleotide #: NM_010776.1
• UniProt Accession #: P41317
• Molecular Weight: 25,957 Da
• NCBI Official Full Name: mannose-binding protein C
• NCBI Official Synonym Full Names: mannose-binding lectin (protein C) 2
• NCBI Official Symbol: Mbl2
• NCBI Official Synonym Symbols: MBL; L-MBP; MBL-C; MBP-C
• NCBI Protein Information: mannose-binding protein C; RARF/P28A; mannan-binding protein; mannose binding lectin (C); RA-reactive factor P28A subunit; mannose binding lectin, liver (C)
• UniProt Protein Name: Mannose-binding protein C
• Protein Family: Mannose-binding protein
• UniProt Gene Name: Mbl2
• UniProt Synonym Gene Names: MBP-C; RARF/P28A
• UniProt Entry Name: MBL2_MOUSE

Uniprot Description

MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; collagen; extracellular region

Molecular Function: mannose binding; protein self-association; protease binding; galactose binding; calcium ion binding; carbohydrate binding; calcium-dependent protein binding; receptor binding

Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; immune system process; positive regulation of phagocytosis; innate immune response; complement activation, lectin pathway; complement activation, classical pathway; negative regulation of viral reproduction