Mitogen-activated protein kinase kinase kinase 2 (MAP3K2) Recombinant Protein | MAP3K2 recombinant protein

Recombinant Human Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)

Cat. Num. AAA1416773

• Gene Names: MAP3K2; MEKK2; MEKK2B
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mitogen-activated protein kinase kinase kinase 2 (MAP3K2); Recombinant Human Mitogen-activated protein kinase kinase kinase 2 (MAP3K2); MAP3K2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-619, Full length protein
• Sequence: MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH
• Sequence Length: 619

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MAP3K2 recombinant protein

This protein is a member of serine
threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

NCBI and Uniprot Product Information

• NCBI GI #: 85838511
• NCBI GeneID: 10746
• NCBI Accession #: NP_006600.3
• NCBI GenBank Nucleotide #: NM_006609.4
• UniProt Accession #: Q9Y2U5; Q53QL9; Q53S75; Q59GZ6; Q8NC32; Q9NYK3; B9EG87
• Molecular Weight: 69,741 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 2
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 2
• NCBI Official Symbol: MAP3K2
• NCBI Official Synonym Symbols: MEKK2; MEKK2B
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 2
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 2
• UniProt Gene Name: MAP3K2
• UniProt Synonym Gene Names: MAPKKK2; MEKK2; MEK kinase 2; MEKK 2

NCBI Description

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (). Plays a role in caveolae kiss-and-run dynamics.