MAGE-like protein 2 (Magel2) Recombinant Protein | Magel2 recombinant protein
Recombinant Mouse MAGE-like protein 2 (Magel2)
Gene Names
Magel2; ns7; nM15; NDNL1; Mage-l2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
MAGE-like protein 2 (Magel2); Recombinant Mouse MAGE-like protein 2 (Magel2); Magel2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-490, full length protein
Sequence
MFIGATFCAPRGASASRAYVPTAWKNLPATSETFPATSRVFPSTSHFQPASSNAFRGPSAASESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPAILMVAAAAPQASATAAEASKSSEPPRRPGKATRKKKHLEPKEDNCGHRLSSRDWRGPRTWGNPSHSDWEIQRAMQLLGDRESLYTPQGLNDWGCPNTSRMPRSLEGPSTSRDQEFCGDSGGSQTWMASEVPSVSRGSSAAQEDPDRESQPLSPLDERANALVQFLLVKDQAKVPVQLSEMVNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDTKTHTYIIVNKMAYPQCNLLASYLERPKFSLLMVVLSLIFMKGYCIRENLLFSFLFQLGLDVQETSGLFRITKKLITSVFVRHRYLEYRQIPFTEPAEYELLWGPRAFLETNRVHILRFLAALYENQPQIWSCQYLDSLAELEYKDANAAAEESHDSDDDAHDPTSSPHPH
Sequence Length
490
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Magel2 recombinant protein
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
137,987 Da
NCBI Official Full Name
MAGE-like protein 2
NCBI Official Synonym Full Names
melanoma antigen, family L, 2
NCBI Official Symbol
Magel2
NCBI Official Synonym Symbols
ns7; nM15; NDNL1; Mage-l2
NCBI Protein Information
MAGE-like protein 2
UniProt Protein Name
MAGE-like protein 2
Protein Family
UniProt Gene Name
Magel2
Uniprot Description
Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (PubMed:22208286).
Research Articles on Magel2
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Product Notes
The Magel2 magel2 (Catalog #AAA1479303) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-490, full length protein. The amino acid sequence is listed below: MFIGATFCAP RGASASRAYV PTAWKNLPAT SETFPATSRV FPSTSHFQPA SSNAFRGPSA ASESPKSLPF ALQDPYACVE ALPAVPWVPY PDGNASSACK SVPAILMVAA AAPQASATAA EASKSSEPPR RPGKATRKKK HLEPKEDNCG HRLSSRDWRG PRTWGNPSHS DWEIQRAMQL LGDRESLYTP QGLNDWGCPN TSRMPRSLEG PSTSRDQEFC GDSGGSQTWM ASEVPSVSRG SSAAQEDPDR ESQPLSPLDE RANALVQFLL VKDQAKVPVQ LSEMVNVVIR EYKDDSLDII NRANTKLECT FGCQLKEVDT KTHTYIIVNK MAYPQCNLLA SYLERPKFSL LMVVLSLIFM KGYCIRENLL FSFLFQLGLD VQETSGLFRI TKKLITSVFV RHRYLEYRQI PFTEPAEYEL LWGPRAFLET NRVHILRFLA ALYENQPQIW SCQYLDSLAE LEYKDANAAA EESHDSDDDA HDPTSSPHPH. It is sometimes possible for the material contained within the vial of "MAGE-like protein 2 (Magel2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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