Human leucine zipper, putative tumor suppressor 1 ELISA Kit | LZTS1 elisa kit
Human Leucine zipper putative tumor suppressor 1, LZTS1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Uniprot Description
LZTS1: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Defects in LZTS1 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the LZTS family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: postsynaptic membrane; apical plasma membrane; postsynaptic density; cytoplasm; dendritic spine; dendritic shaft; cell junction
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: negative regulation of macroautophagy; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of dendrite morphogenesis; cell cycle
Disease: Esophageal Cancer
Research Articles on LZTS1
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Product Notes
The Human LZTS1 lzts1 (Catalog #AAA9334847) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334847 ELISA Kit recognizes Human LZTS1. It is sometimes possible for the material contained within the vial of "leucine zipper, putative tumor suppressor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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