Rabbit LZTS1 Polyclonal Antibody | anti-LZTS1 antibody

LZTS1 Rabbit Polyclonal

Cat. Num. AAA7601150

• Gene Names: LZTS1; F37; FEZ1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LZTS1; Polyclonal Antibody; LZTS1 Rabbit Polyclonal; anti-LZTS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 596

• Applicable Applications for anti-LZTS1 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
• Immunogen: Leucine zipper, putative tumor suppressor 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7601150 (LZTS1 antibody) at dilution of 1:5000)

NCBI and Uniprot Product Information

• NCBI GI #: 10440566
• NCBI GeneID: 11178
• NCBI Accession #: NP_066300.1
• NCBI GenBank Nucleotide #: NM_021020.3
• Molecular Weight: 8,571 Da
• NCBI Official Full Name: leucine zipper putative tumor suppressor 1
• NCBI Official Synonym Full Names: leucine zipper, putative tumor suppressor 1
• NCBI Official Symbol: LZTS1
• NCBI Official Synonym Symbols: F37; FEZ1
• NCBI Protein Information: leucine zipper putative tumor suppressor 1
• UniProt Protein Name: Leucine zipper putative tumor suppressor 1
• Protein Family: Leucine zipper putative tumor suppressor
• UniProt Gene Name: LZTS1
• UniProt Synonym Gene Names: FEZ1
• UniProt Entry Name: LZTS1_HUMAN

NCBI Description

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

Uniprot Description

LZTS1: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Defects in LZTS1 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the LZTS family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Transcription factor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: apical plasma membrane; cell junction; cytoplasm; dendritic shaft; dendritic spine; postsynaptic density; postsynaptic membrane

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: cell cycle; negative regulation of macroautophagy; regulation of dendrite morphogenesis; regulation of synaptic plasticity; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Esophageal Cancer