CD85e recombinant protein

Recombinant Human CD85e protein, C-His Tag

Cat. Num. AAA1560557

• Gene Names: LILRA3; HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD85e; Recombinant Human CD85e protein; C-His Tag; LILRA3; CD85e recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human LILRA3 (Met1-Glu439) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD85e recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 289547633
• NCBI GeneID: 11026
• NCBI Accession #: NP_001166125.1
• NCBI GenBank Nucleotide #: NM_001172654.2
• UniProt Accession #: Q8N6C8; O15469; O15470; O75016; Q8N151; Q8N154; Q8NHJ1; Q8NHJ2; Q8NHJ3; Q8NHJ4; J3KPM2
• Molecular Weight: 49,187 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A3
• NCBI Official Symbol: LILRA3
• NCBI Official Synonym Symbols: HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 3
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 3
• UniProt Gene Name: LILRA3
• UniProt Synonym Gene Names: ILT6; LIR4; ILT-6; LIR-4

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

Uniprot Description

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.